Osteoporosis treatment: recent developments and ongoing challenges

S Khosla, LC Hofbauer - The lancet Diabetes & endocrinology, 2017 - thelancet.com
Osteoporosis is an enormous and growing public health problem. Once considered an
inevitable consequence of ageing, it is now eminently preventable and treatable. Ironically …

T-cell mediated inflammation in postmenopausal osteoporosis

D Wu, A Cline-Smith, E Shashkova, A Perla… - Frontiers in …, 2021 - frontiersin.org
Osteoporosis is the most prevalent metabolic bone disease that affects half the women in the
sixth and seventh decade of life. Osteoporosis is characterized by uncoupled bone …

Vitamin D deficiency, osteoporosis and effect on autoimmune diseases and hematopoiesis: a review

M De Martinis, A Allegra, MM Sirufo, A Tonacci… - International journal of …, 2021 - mdpi.com
Vitamin D (VD) is essential for bone homeostasis, but it is also involved in pleiotropic effects
on various organs and tissues. In adults, VD deficiency can cause or exacerbate …

An update on therapies for the treatment of diabetes-induced osteoporosis

S Mohsin, MMYH Baniyas… - Expert opinion on …, 2019 - Taylor & Francis
Introduction: Currently, 424 million people aged between 20 and 79 years worldwide are
diabetic. More than 25% of adults aged over 65 years in North America have Type 2 …

A systematic review and meta-analysis of efficacy and safety of Romosozumab in postmenopausal osteoporosis

S Singh, S Dutta, S Khasbage, T Kumar… - Osteoporosis …, 2022 - Springer
The study was conducted to illustrate the effect of Romosozumab in postmenopausal
osteoporosis patients. Romosozumab decreased the incidence of vertebral, nonvertebral …

A high‐throughput biomimetic bone‐on‐a‐chip platform with artificial intelligence‐assisted image analysis for osteoporosis drug testing

K Paek, S Kim, S Tak, MK Kim, J Park… - Bioengineering & …, 2023 - Wiley Online Library
Although numerous organ‐on‐a‐chips have been developed, bone‐on‐a‐chip platforms
have rarely been reported because of the high complexity of the bone microenvironment …

Advancement in the treatment of osteoporosis and the effects on bone healing

Y Kushchayeva, I Pestun, S Kushchayev… - Journal of Clinical …, 2022 - mdpi.com
Osteoporosis (OP) is a major global health concern, with aging being one of the most
important risk factors. Osteoarthritis (OA) is also an age-related disorder. Patients with OP …

Prospect of mesenchymal stem cells in therapy of osteoporosis: a review

L Aghebati‐Maleki, S Dolati, R Zandi… - Journal of cellular …, 2019 - Wiley Online Library
Osteoporosis is a systemic skeletal disease associated with reduced bone strong point that
results in raised fracture risk, with decreased bone strength, leading to reduced bone …

Efficacy and safety of romosozumab among postmenopausal women with osteoporosis and mild‐to‐moderate chronic kidney disease

PD Miller, JD Adachi, BH Albergaria… - Journal of Bone and …, 2020 - academic.oup.com
Patients with osteoporosis and chronic kidney disease (CKD) are at increased risk of
fracture and associated negative outcomes, including increased mortality. The present post …

Lowering of circulating sclerostin may increase risk of atherosclerosis and its risk factors: evidence from a genome‐wide association meta‐analysis followed by …

J Zheng, E Wheeler, M Pietzner… - Arthritis & …, 2023 - Wiley Online Library
Objective In this study, we aimed to establish the causal effects of lowering sclerostin, target
of the antiosteoporosis drug romosozumab, on atherosclerosis and its risk factors. Methods …