The visualization of whole organs and organisms through tissue clearing and fluorescence
volumetric imaging has revolutionized the way we look at biological samples. Its application …

The cerebral vasculature is a dense network of arteries, capillaries, and veins. Quantifying
variations of the vascular organization across individuals, brain regions, or disease models …

Tissue clearing methods enable the imaging of biological specimens without sectioning.
However, reliable and scalable analysis of large imaging datasets in three dimensions …

This review delves into the rapidly evolving field of deep tissue imaging at cellular
resolution, reviewing popular tissue clearing and staining methods in combination with light …

Clinically relevant brain metastases (BMs) frequently form in cancer patients, with limited
options for effective treatment. Circulating cancer cells must first permanently arrest in brain …

Innate immune cells play a key role in the pathogenesis of multiple sclerosis and
experimental autoimmune encephalomyelitis (EAE). Current clinical imaging is restricted to …

Glioblastoma is the most common malignant primary brain tumor with poor overall survival.
Magnetic resonance imaging (MRI) is the main imaging modality for glioblastoma but has …

Rationale: Glioblastoma is the most frequent, primary brain tumor that is characterized by a
highly immunosuppressive tumor microenvironment (TME). The TME plays a key role for …

Glioblastoma multiforme alters healthy tissue vasculature by inducing angiogenesis and
vascular remodeling. To fully comprehend the structural and functional properties of the …

Magnetic resonance imaging (MRI) and light-sheet fluorescence microscopy (LSFM) are
technologies that enable non-disruptive 3-dimensional imaging of whole mouse brains. A …