The dorsal horns of the spinal cord and the trigeminal nuclei in the brainstem contain neuron
populations that are critical to process sensory information. Neurons in these areas are …

Pain is a percept of critical importance to our daily survival. In most cases, it serves both an
adaptive function by helping us respond appropriately in a potentially hostile environment …

Single-cell RNA sequencing data can unveil the molecular diversity of cell types. Cell type
atlases of the mouse spinal cord have been published in recent years but have not been …

Central sensitization caused by spinal disinhibition is a key mechanism of mechanical
allodynia in neuropathic pain. However, the molecular mechanisms underlying spinal …

The encoding of touch in the spinal cord dorsal horn (DH) and its influence on tactile
representations in the brain are poorly understood. Using a range of mechanical stimuli …

Background Previous studies have confirmed that the microglial activation and subsequent
inflammatory responses in the trigeminal nucleus caudalis (TNC) are involved in the central …

Neuropathic pain is a debilitating condition resulting from damage to the nervous system.
Imbalance of spinal excitation and inhibition has been proposed to contribute to neuropathic …

Central neuropathic pain arises from a lesion or disease of the central somatosensory
nervous system such as brain injury, spinal cord injury, stroke, multiple sclerosis or related …

The peripheral somatosensory system bestows mammals with a diverse repertoire of
sensory modalities: gentle touch, mechanical pain, itch, thermosensation, and …

Peripheral nerve injury sensitizes a complex network of spinal cord dorsal horn (DH)
neurons to produce allodynia and neuropathic pain. The identification of a druggable target …