Since the serendipitous discovery of the biological activity of cisplatin, 1 the drug has been
applied extensively in cancer chemotherapy. 2 Platinum-based drugs such as cisplatin …

Cisplatin, carboplatin, and oxaliplatin are three FDA-approved members of the platinum
anticancer drug family. These compounds induce apoptosis in tumor cells by binding to …

Cisplatin is a chemotherapeutic agent that is widely used to treat a variety of malignant
tumors. Serious dose-limiting side effects like ototoxicity, nephrotoxicity and neurotoxicity …

The human genome, comprising three billion base pairs coding for 30000–40000 genes, is
constantly attacked by endogenous reactive metabolites, therapeutic drugs and a plethora of …

Cisplatin is a highly effective chemotherapeutic agent that is widely used to treat solid organ
malignancies. However, serious side effects have been associated with its use, such as …

Sensitivity and resistance of cells to platinum drug chemotherapy are to a large extent
determined by activity of the DNA damage response (DDR). Combining chemotherapy with …

Cellular DNA is continuously transcribed into RNA by multisubunit RNA polymerases
(RNAPs). The continuity of transcription can be disrupted by DNA lesions that arise from the …

The anticancer drug cisplatin forms 1, 2-d (GpG) DNA intrastrand cross-links (cisplatin
lesions) that stall RNA polymerase II (Pol II) and trigger transcription-coupled DNA repair …

Various DNA sequences that interfere with transcription due to their unusual structural
properties have been implicated in the regulation of gene expression and with genomic …

UV-induced cyclobutane pyrimidine dimers (CPDs) in the template DNA strand stall
transcription elongation by RNA polymerase II (Pol II). If the nucleotide excision repair …