Introduction Alzheimer's disease (AD) progression follows a specific spreading pattern,
emphasizing the need to characterize those brain areas that degenerate first. The …

Clarifying the relationships between neuropsychiatric symptoms and Alzheimer's disease
(AD)-related pathology may open avenues for effective treatments. Here, we investigate the …

Alzheimer's disease (AD) is a severe neurodegenerative disorder still in search of effective
methods of diagnosis. Altered levels of the NMDA receptor co-agonist, d-serine, have been …

Dementia is more prevalent in Blacks than in Whites, likely due to a combination of
environmental and biological factors. Paradoxically, clinical studies suggest an attenuation …

Objective: We conducted a clinicopathologic study in a large population with very low levels
of education to determine whether very few years of education could contribute to cognitive …

Alzheimer's disease is the commonest cause of dementia in the elderly, but its pathological
determinants are still debated. Amyloid-β plaques and neurofibrillary tangles have been …

Background Clinicopathological studies are important in determining the brain lesions
underlying dementia. Although almost 60% of individuals with dementia live in developing …

Clarifying the mechanisms connecting neurofibrillary tangle (NFT) neurotoxicity to neuronal
dysfunction in humans is likely to be pivotal for developing effective treatments for …

Although the cognitive impairment in Alzheimer's disease (AD) is believed to be caused by
amyloid-β (Aβ) plaques and neurofibrillary tangles (NFTs), several postmortem studies have …

Alzheimer's disease (AD) is characterized by progressive cognitive decline associated with
a featured neuropathology (neuritic plaques and neurofibrillary tangles). Several studies …