The evolving story of incretins (GIP and GLP‐1) in metabolic and cardiovascular disease: a pathophysiological update
MA Nauck, DR Quast, J Wefers… - Diabetes, Obesity and …, 2021 - Wiley Online Library
The incretin hormones glucose‐dependent insulinotropic polypeptide (GIP) and glucagon‐
like peptide‐1 (GLP‐1) have their main physiological role in augmenting insulin secretion …
like peptide‐1 (GLP‐1) have their main physiological role in augmenting insulin secretion …
Cardiovascular actions and clinical outcomes with glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors
MA Nauck, JJ Meier, MA Cavender, M Abd El Aziz… - Circulation, 2017 - Am Heart Assoc
Potentiation of glucagon-like peptide-1 (GLP-1) action through selective GLP-1 receptor
(GLP-1R) agonism or by prevention of enzymatic degradation by inhibition of dipeptidyl …
(GLP-1R) agonism or by prevention of enzymatic degradation by inhibition of dipeptidyl …
[HTML][HTML] The cardiovascular biology of glucagon-like peptide-1
DJ Drucker - Cell metabolism, 2016 - cell.com
Glucagon-like peptide-1, produced predominantly in enteroendocrine cells, controls glucose
metabolism and energy homeostasis through regulation of islet hormone secretion …
metabolism and energy homeostasis through regulation of islet hormone secretion …
[HTML][HTML] Pleiotropic effects of GLP-1 and analogs on cell signaling, metabolism, and function
J Rowlands, J Heng, P Newsholme… - Frontiers in …, 2018 - frontiersin.org
The incretin hormone Glucagon-Like Peptide-1 (GLP-1) is best known for its “incretin effect”
in restoring glucose homeostasis in diabetics, however, it is now apparent that it has a …
in restoring glucose homeostasis in diabetics, however, it is now apparent that it has a …
Stunned and hibernating myocardium: where are we nearly 4 decades later?
RA Kloner - Journal of the American Heart Association, 2020 - Am Heart Assoc
Background In 1982, Braunwald and Kloner 1 described stunning as “prolonged, post‐
ischemic ventricular dysfunction that occurs after brief periods of nonlethal ischemia.” They …
ischemic ventricular dysfunction that occurs after brief periods of nonlethal ischemia.” They …
[HTML][HTML] Effects of GLP-1 receptor agonists and SGLT-2 inhibitors on cardiac structure and function: a narrative review of clinical evidence
The impressive results of recent clinical trials with glucagon-like peptide-1 receptor agonists
(GLP-1Ra) and sodium glucose transporter 2 inhibitors (SGLT-2i) in terms of cardiovascular …
(GLP-1Ra) and sodium glucose transporter 2 inhibitors (SGLT-2i) in terms of cardiovascular …
Myocardial stunning and hibernation revisited
G Heusch - Nature Reviews Cardiology, 2021 - nature.com
Unlike acute myocardial infarction with reperfusion, in which infarct size is the end point
reflecting irreversible injury, myocardial stunning and hibernation result from reversible …
reflecting irreversible injury, myocardial stunning and hibernation result from reversible …
Glucagon‐like peptide‐1 (GLP‐1) receptor agonists and their cardiovascular benefits—The role of the GLP‐1 receptor
J Helmstädter, K Keppeler, L Küster… - British journal of …, 2022 - Wiley Online Library
Cardiovascular outcome trials revealed cardiovascular benefits for type 2 diabetes mellitus
patients when treated with long‐acting glucagon‐like peptide‐1 (GLP‐1) receptor agonists …
patients when treated with long‐acting glucagon‐like peptide‐1 (GLP‐1) receptor agonists …
[HTML][HTML] Circulating mediators of remote ischemic preconditioning: search for the missing link between non-lethal ischemia and cardioprotection
M Billah, A Ridiandries, U Allahwala, H Mudaliar… - Oncotarget, 2019 - ncbi.nlm.nih.gov
Acute myocardial infarction (AMI) is one of the leading causes of mortality and morbidity
worldwide. There has been an extensive search for cardioprotective therapies to reduce …
worldwide. There has been an extensive search for cardioprotective therapies to reduce …
[HTML][HTML] Mitochondrial dysfunction and its impact on diabetic heart
Mitochondrial dysfunction and associated oxidative stress are strongly linked to
cardiovascular, neurodegenerative, and age associated disorders. More specifically …
cardiovascular, neurodegenerative, and age associated disorders. More specifically …