Scavenger receptors in homeostasis and immunity
Scavenger receptors were originally identified by their ability to recognize and to remove
modified lipoproteins; however, it is now appreciated that they carry out a striking range of …
modified lipoproteins; however, it is now appreciated that they carry out a striking range of …
[HTML][HTML] A ceramide-centric view of insulin resistance
JA Chavez, SA Summers - Cell metabolism, 2012 - cell.com
The recent implementation of genomic and lipidomic approaches has produced a large
body of evidence implicating the sphingolipid ceramide in a diverse range of physiological …
body of evidence implicating the sphingolipid ceramide in a diverse range of physiological …
Membrane fatty acid transporters as regulators of lipid metabolism: implications for metabolic disease
JFC Glatz, JJFP Luiken, A Bonen - Physiological reviews, 2010 - journals.physiology.org
Long-chain fatty acids and lipids serve a wide variety of functions in mammalian
homeostasis, particularly in the formation and dynamic properties of biological membranes …
homeostasis, particularly in the formation and dynamic properties of biological membranes …
AMPK regulation of fatty acid metabolism and mitochondrial biogenesis: implications for obesity
Skeletal muscle plays an important role in regulating whole-body energy expenditure given
it is a major site for glucose and lipid oxidation. Obesity and type 2 diabetes are causally …
it is a major site for glucose and lipid oxidation. Obesity and type 2 diabetes are causally …
PGC-1α regulation by exercise training and its influences on muscle function and insulin sensitivity
The peroxisome proliferator-activated receptor-γ (PPARγ) coactivator-1α (PGC-1α) is a
major regulator of exercise-induced phenotypic adaptation and substrate utilization. We …
major regulator of exercise-induced phenotypic adaptation and substrate utilization. We …
[HTML][HTML] Mitochondrial and cellular mechanisms for managing lipid excess
Current scientific debates center on the impact of lipids and mitochondrial function on
diverse aspects of human health, nutrition and disease, among them the association of …
diverse aspects of human health, nutrition and disease, among them the association of …
Fatty acid transport across the cell membrane: regulation by fatty acid transporters
RW Schwenk, GP Holloway, JJFP Luiken… - … and Essential Fatty …, 2010 - Elsevier
Transport of long-chain fatty acids across the cell membrane has long been thought to occur
by passive diffusion. However, in recent years there has been a fundamental shift in …
by passive diffusion. However, in recent years there has been a fundamental shift in …
Insulin resistance and mitochondrial dysfunction
A Gonzalez-Franquesa, ME Patti - Mitochondrial Dynamics in …, 2017 - Springer
Insulin resistance precedes and predicts the onset of type 2 diabetes (T2D) in susceptible
humans, underscoring its important role in the complex pathogenesis of this disease. Insulin …
humans, underscoring its important role in the complex pathogenesis of this disease. Insulin …
Exercise training increases sarcolemmal and mitochondrial fatty acid transport proteins in human skeletal muscle
Fatty acid oxidation is highly regulated in skeletal muscle and involves several sites of
regulation, including the transport of fatty acids across both the plasma and mitochondrial …
regulation, including the transport of fatty acids across both the plasma and mitochondrial …
Obesity-associated insulin resistance in skeletal muscle: role of lipid accumulation and physical inactivity
K Eckardt, A Taube, J Eckel - Reviews in Endocrine and Metabolic …, 2011 - Springer
An alarming increase in the prevalence of obesity, type 2 diabetes mellitus, and associated
diseases can be observed world-wide during the past 20 years. In obesity, profound …
diseases can be observed world-wide during the past 20 years. In obesity, profound …