Alternative splicing regulatory networks: functions, mechanisms, and evolution
J Ule, BJ Blencowe - Molecular cell, 2019 - cell.com
High-throughput sequencing-based methods and their applications in the study of
transcriptomes have revolutionized our understanding of alternative splicing. Networks of …
transcriptomes have revolutionized our understanding of alternative splicing. Networks of …
Targeting mRNA processing as an anticancer strategy
J Desterro, P Bak-Gordon… - Nature Reviews Drug …, 2020 - nature.com
Discoveries in the past decade have highlighted the potential of mRNA as a therapeutic
target for cancer. Specifically, RNA sequencing revealed that, in addition to gene mutations …
target for cancer. Specifically, RNA sequencing revealed that, in addition to gene mutations …
Transcription factors interact with RNA to regulate genes
O Oksuz, JE Henninger, R Warneford-Thomson… - Molecular cell, 2023 - cell.com
Transcription factors (TFs) orchestrate the gene expression programs that define each cell's
identity. The canonical TF accomplishes this with two domains, one that binds specific DNA …
identity. The canonical TF accomplishes this with two domains, one that binds specific DNA …
PRMT inhibition induces a viral mimicry response in triple-negative breast cancer
Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype with the
worst prognosis and few effective therapies. Here we identified MS023, an inhibitor of type I …
worst prognosis and few effective therapies. Here we identified MS023, an inhibitor of type I …
Alternative start and termination sites of transcription drive most transcript isoform differences across human tissues
Most human genes generate multiple transcript isoforms. The differential expression of these
isoforms can help specify cell types. Diverse transcript isoforms arise from the use of …
isoforms can help specify cell types. Diverse transcript isoforms arise from the use of …
[HTML][HTML] SARS-CoV-2 nucleocapsid protein binds host mRNAs and attenuates stress granules to impair host stress response
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleocapsid (N) protein is
essential for viral replication, making it a promising target for antiviral drug and vaccine …
essential for viral replication, making it a promising target for antiviral drug and vaccine …
Epithelial–mesenchymal-transition-inducing transcription factors: new targets for tackling chemoresistance in cancer?
J van Staalduinen, D Baker, P Ten Dijke, H van Dam - Oncogene, 2018 - nature.com
Chemoresistance remains a major complication of cancer treatments. Recent data provide
strong evidence that chemoresistance is linked to epithelial–mesenchymal transition (EMT) …
strong evidence that chemoresistance is linked to epithelial–mesenchymal transition (EMT) …
Splicing-associated chromatin signatures: a combinatorial and position-dependent role for histone marks in splicing definition
Alternative splicing relies on the combinatorial recruitment of splicing regulators to specific
RNA binding sites. Chromatin has been shown to impact this recruitment. However, a limited …
RNA binding sites. Chromatin has been shown to impact this recruitment. However, a limited …
Regulation of alternative polyadenylation by the C2H2-zinc-finger protein Sp1
Alternative polyadenylation (APA) enhances gene regulatory potential by increasing the
diversity of mRNA transcripts. 3′ UTR shortening through APA correlates with enhanced …
diversity of mRNA transcripts. 3′ UTR shortening through APA correlates with enhanced …