During oncogenesis, cancer not only escapes the body's regulatory mechanisms, but also
gains the ability to affect local and systemic homeostasis. Specifically, tumors produce …

The skin, which is comprised of the epidermis, dermis, and subcutaneous tissue, is the
largest organ in the human body and it plays a crucial role in the regulation of the body's …

Ultraviolet radiation (UVR) is primarily recognized for its detrimental effects such as
cancerogenesis, skin aging, eye damage, and autoimmune disorders. With exception of …

The skin, being the largest organ in the human body, is exposed to the environment and
suffers from both intrinsic and extrinsic aging factors. The skin aging process is …

Background: Melatonin synchronizes central but also peripheral oscillators (fetal adrenal
gland, pancreas, liver, kidney, heart, lung, fat, gut, etc.), allowing temporal organization of …

The skin, a self-regulating protective barrier organ, is empowered with sensory and
computing capabilities to counteract the environmental stressors to maintain and restore …

The active metabolites of vitamin D3 (D3) and lumisterol (L3) exert a variety of antiaging and
photoprotective effects on the skin. These are achieved through immunomodulation and …

Melatonin, an evolutionarily ancient derivative of serotonin with hormonal properties, is the
main neuroendocrine secretory product of the pineal gland. Although melatonin is best …

Melatonin modulates a wide range of physiological functions with pleiotropic effects on the
immune system. Despite the large number of reports implicating melatonin as an …

Human skin exposed to solar ultraviolet radiation (UVR) results in a dramatic increase in the
production of reactive oxygen species (ROS). The sudden increase in ROS shifts the natural …