Trends in peptide drug discovery
Since the introduction of insulin almost a century ago, more than 80 peptide drugs have
reached the market for a wide range of diseases, including diabetes, cancer, osteoporosis …
reached the market for a wide range of diseases, including diabetes, cancer, osteoporosis …
Lessons learned from clinical trials using antimicrobial peptides (AMPs)
GS Dijksteel, MMW Ulrich, E Middelkoop… - Frontiers in …, 2021 - frontiersin.org
Antimicrobial peptides (AMPs) or host defense peptides protect the host against various
pathogens such as yeast, fungi, viruses and bacteria. AMPs also display immunomodulatory …
pathogens such as yeast, fungi, viruses and bacteria. AMPs also display immunomodulatory …
Design, optimization, and nanotechnology of antimicrobial peptides: From exploration to applications
P Tan, H Fu, X Ma - Nano Today, 2021 - Elsevier
Antibiotic resistance caused by antibiotic abuse, especially the emergence of multi-drug
resistant bacteria, poses a serious threat to human health, and makes it imperative to find …
resistant bacteria, poses a serious threat to human health, and makes it imperative to find …
Antimicrobial peptides: diversity, mechanism of action and strategies to improve the activity and biocompatibility in vivo
Antibiotic resistance is projected as one of the greatest threats to human health in the future
and hence alternatives are being explored to combat resistance. Antimicrobial peptides …
and hence alternatives are being explored to combat resistance. Antimicrobial peptides …
[HTML][HTML] Oral delivery of proteins and peptides: Challenges, status quo and future perspectives
Proteins and peptides (PPs) have gradually become more attractive therapeutic molecules
than small molecular drugs due to their high selectivity and efficacy, but fewer side effects …
than small molecular drugs due to their high selectivity and efficacy, but fewer side effects …
Understanding cell penetration of cyclic peptides
Approximately 75% of all disease-relevant human proteins, including those involved in
intracellular protein–protein interactions (PPIs), are undruggable with the current drug …
intracellular protein–protein interactions (PPIs), are undruggable with the current drug …
Strategies employed in the design of antimicrobial peptides with enhanced proteolytic stability
Z Lai, X Yuan, H Chen, Y Zhu, N Dong, A Shan - Biotechnology Advances, 2022 - Elsevier
Due to the alarming developing rate of multidrug-resistant bacterial pathogens, the
development and modification of antimicrobial peptides (AMPs) are unprecedentedly active …
development and modification of antimicrobial peptides (AMPs) are unprecedentedly active …
[HTML][HTML] Dengue virus infection–a review of pathogenesis, vaccines, diagnosis and therapy
The transmission of dengue virus (DENV) from an infected Aedes mosquito to a human,
causes illness ranging from mild dengue fever to fatal dengue shock syndrome. The similar …
causes illness ranging from mild dengue fever to fatal dengue shock syndrome. The similar …
Antimicrobial peptides–Advances in development of therapeutic applications
The severe infection is becoming a significant health problem which threaten the lives of
patients and the safety and economy of society. In the way of finding new strategy …
patients and the safety and economy of society. In the way of finding new strategy …
In Silico Approach for Predicting Toxicity of Peptides and Proteins
Background Over the past few decades, scientific research has been focused on developing
peptide/protein-based therapies to treat various diseases. With the several advantages over …
peptide/protein-based therapies to treat various diseases. With the several advantages over …