Flipping the metabolic switch: understanding and applying the health benefits of fasting
SD Anton, K Moehl, WT Donahoo, K Marosi, SA Lee… - …, 2018 - Wiley Online Library
Objective Intermittent fasting (IF) is a term used to describe a variety of eating patterns in
which no or few calories are consumed for time periods that can range from 12 hours to …
which no or few calories are consumed for time periods that can range from 12 hours to …
Role of inactivity in chronic diseases: evolutionary insight and pathophysiological mechanisms
FW Booth, CK Roberts, JP Thyfault… - Physiological …, 2017 - journals.physiology.org
This review proposes that physical inactivity could be considered a behavior selected by
evolution for resting, and also selected to be reinforcing in life-threatening situations in …
evolution for resting, and also selected to be reinforcing in life-threatening situations in …
Intermittent metabolic switching, neuroplasticity and brain health
MP Mattson, K Moehl, N Ghena… - Nature Reviews …, 2018 - nature.com
During evolution, individuals whose brains and bodies functioned well in a fasted state were
successful in acquiring food, enabling their survival and reproduction. With fasting and …
successful in acquiring food, enabling their survival and reproduction. With fasting and …
Brain metabolism in health, aging, and neurodegeneration
S Camandola, MP Mattson - The EMBO journal, 2017 - embopress.org
Brain cells normally respond adaptively to bioenergetic challenges resulting from ongoing
activity in neuronal circuits, and from environmental energetic stressors such as food …
activity in neuronal circuits, and from environmental energetic stressors such as food …
Hippocampal insulin resistance and cognitive dysfunction
GJ Biessels, LP Reagan - Nature Reviews Neuroscience, 2015 - nature.com
Clinical studies suggest a link between type 2 diabetes mellitus (T2DM) and insulin
resistance (IR) and cognitive dysfunction, but there are significant gaps in our knowledge of …
resistance (IR) and cognitive dysfunction, but there are significant gaps in our knowledge of …
An umbrella review of randomized control trials on the effects of physical exercise on cognition
Extensive research links regular physical exercise to an overall enhancement of cognitive
function across the lifespan. Here we assess the causal evidence supporting this …
function across the lifespan. Here we assess the causal evidence supporting this …
Exercise is the real polypill
C Fiuza-Luces, N Garatachea, NA Berger… - Physiology, 2013 - journals.physiology.org
The concept of a “polypill” is receiving growing attention to prevent cardiovascular disease.
Yet similar if not overall higher benefits are achievable with regular exercise, a drug-free …
Yet similar if not overall higher benefits are achievable with regular exercise, a drug-free …
TNF-α differentially regulates synaptic plasticity in the hippocampus and spinal cord by microglia-dependent mechanisms after peripheral nerve injury
Clinical studies show that chronic pain is accompanied by memory deficits and reduction in
hippocampal volume. Experimental studies show that spared nerve injury (SNI) of the sciatic …
hippocampal volume. Experimental studies show that spared nerve injury (SNI) of the sciatic …
The effects of physical activity and exercise on brain‐derived neurotrophic factor in healthy humans: A review
The purpose of this study was to summarize the effects of physical activity and exercise on
peripheral brain‐derived neurotrophic factor (BDNF) in healthy humans. Experimental and …
peripheral brain‐derived neurotrophic factor (BDNF) in healthy humans. Experimental and …
BDNF mediates improvements in executive function following a 1-year exercise intervention
Executive function declines with age, but engaging in aerobic exercise may attenuate
decline. One mechanism by which aerobic exercise may preserve executive function is …
decline. One mechanism by which aerobic exercise may preserve executive function is …