COVID-19 poses an extraordinary threat to global public health and an effective vaccine
could provide a key means of overcoming this crisis. Human challenge studies involve the …

Development of an effective vaccine is the clearest path to controlling the coronavirus
disease 2019 (COVID-19) pandemic. To accelerate vaccine development, some …

Human infection challenge studies (HCS) involve intentionally infecting research
participants with pathogens (or other micro-organisms). There have been recent calls for …

This report of the WHO Working Group for Guidance on Human Challenge Studies in COVID-
19 outlines ethical standards for COVID-19 challenge studies. It includes eight Key Criteria …

The pandemic of coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, poses an
extraordinary threat to global public health, socioeconomic stability, food security and other …

Although the principle of fair subject selection is a widely recognized requirement of ethical
clinical research, it often yields conflicting imperatives, thus raising major ethical dilemmas …

To prepare for potential human infection challenge studies (HICS) involving SARS-CoV-2,
we convened a multidisciplinary working group to address ethical questions regarding …

Secondary analysis of digital psychological data (DPD) is an increasingly popular method
for behavioral health research. Under current practices, secondary research does not …

With decades of pre‐clinical studies culminating in the recent clinical application of
xenotransplantation, it would appear timely to provide recommendations for operationalizing …

Analytical treatment interruptions (ATIs) have become a key methodological approach to
evaluate the effects of experimental HIV cure-related research interventions. During ATIs …