Regenerative bone implants have been designed to promote new bone formation, however,
the search for a suitable implant remains challenging despite the use of various biomaterials …

The treatment of patients with advanced cancer poses clinical problems due to the
complications that arise as the disease progresses. Bone metastases are a common …

Metastatic spread of tumour cells to tissues and organs around the body is the most frequent
cause of death from breast cancer. This has been modelled mainly using mouse models …

Increased fibrotic extracellular matrix (ECM) deposition promotes tumor invasion, which is
the first step of the metastatic cascade. Yet, the underlying mechanisms are poorly …

Skeletal metastasis is common in patients with advanced breast cancer and often caused by
immune evasion of disseminated tumor cells (DTCs). In the skeleton, tumor cells not only …

Bone is highly susceptible to cancer metastasis, and both tumor and bone cells enable
tumor invasion through a" vicious cycle" of biochemical signaling. Tumor metastasis into …

Purpose Vitamin D has some anticancer properties that may decrease breast cancer risk
and improve prognosis. The aim was to investigate associations between four previously …

Bone is a dynamic mineralized tissue that undergoes continuous turnover throughout life.
While the general mechanism of bone mineral metabolism is documented, the role of …

Understanding cancer metastasis is crucial for advancing therapeutic strategies and
improving clinical outcomes. Cancer cells face dynamic changes in their mechanical …

Breast cancer (BC) represents a multifaceted malignancy, with escalating incidence and
mortality rates annually. Chemotherapy stands as an indispensable approach for treating …