Autophagy plays a key role in the maintenance of cellular homeostasis. In healthy cells,
such a homeostatic activity constitutes a robust barrier against malignant transformation …

DNA methylation is a crucial epigenetic modification of the genome that is involved in
regulating many cellular processes. These include embryonic development, transcription …

Cancer is widely perceived as a heterogeneous group of disorders with markedly different
biological properties, which are caused by a series of clonally selected genetic changes in …

The tumor oncoproteins HRAS, KRAS, and NRAS are the founding members of a larger
family of at least 35 related human proteins. Using a somewhat broader definition of …

The epithelial ovarian carcinomas, which make up more than 85% of human ovarian cancer,
arise in the ovarian surface epithelium (OSE). The etiology and early events in the …

Abstract c-Abl is normally regulated by an autoinhibitory mechanism, the disruption of which
leads to chronic myelogenous leukemia. The details of this mechanism have been elusive …

The role of autophagy in oncogenesis remains ambiguous, and mechanisms that induce
autophagy and regulate its outcome in human cancers are poorly understood. The …

DNA methylation is not just for basic scientists any more. There is a growing awareness in
the medical field that having the correct pattern of genomic methylation is essential for …

Ovarian carcinogenesis, as in most cancers, involves multiple genetic alterations. A great
deal has been learned about proteins and pathways important in the early stages of …

Abstract Knowledge about breast carcinogenesis has accumulated during the last decades
but has barely been translated into strategies for early detection or prevention of this …