Natural selection and recombination at host-interacting lipoprotein loci drive genome diversification of Lyme disease and related bacteria

S Akther, EF Mongodin, RD Morgan, L Di, X Yang… - MBio, 2024 - journals.asm.org
Lyme disease, caused by spirochetes in the Borrelia burgdorferi sensu lato clade within the
Borrelia genus, is transmitted by Ixodes ticks and is currently the most prevalent and rapidly …

Analysis of the Borreliaceae Pangenome Reveals a Distinct Genomic Architecture Conserved Across Phylogenetic Scales

JE Lemieux - The Journal of Infectious Diseases, 2024 - academic.oup.com
The family Borreliaceae contains arthropod-borne spirochetes that cause two widespread
human diseases, Lyme disease and relapsing fever. Lyme disease is a subacute …

[HTML][HTML] Combining short-and long-read sequencing unveils geographically structured diversity in Borrelia miyamotoi

D Hoornstra, KV Kuleshov, V Fingerle, S Hepner… - Iscience, 2024 - cell.com
Borrelia miyamotoi is an emerging Ixodes tick-borne human pathogen in the Northern
hemisphere. The aim of the current study was to compare whole genome sequences of B …

[HTML][HTML] Genome diversity of Borrelia garinii in marine transmission cycles does not match host associations but reflects the strains evolutionary history

G Margos, M Hofmann, S Casjens, M Dupraz… - Infection, Genetics and …, 2023 - Elsevier
Borrelia burgdorferi sensu lato is a species complex of spirochetal bacteria that occupy
different ecological niches which is reflected in their reservoir host-and vector-associations …

Salmonella Typhimurium with Eight Tandem Copies of blaNDM-1 on a HI2 Plasmid

H Song, S Zou, Y Huang, C Jian, W Liu, L Tian, L Gong… - Microorganisms, 2023 - mdpi.com
Carbapenem-resistant Salmonella has recently aroused increasing attention. In this study, a
total of four sequence type 36 Salmonella enterica subsp. enterica serovar Typhimurium (S …

Many purported pseudogenes in bacterial genomes are bona fide genes

NP Cooley, ES Wright - BMC genomics, 2024 - Springer
Background Microbial genomes are largely comprised of protein coding sequences, yet
some genomes contain many pseudogenes caused by frameshifts or internal stop codons …

Meta-analysis of the Vmp-like sequences of Lyme disease Borrelia: evidence for the evolution of an elaborate antigenic variation system

SJ Norris, K Brangulis - Frontiers in Microbiology, 2024 - frontiersin.org
VMP-like sequence (vls) antigenic variation systems are present in every Lyme disease
Borrelia strain with complete genome sequences. The linear plasmid-encoded vls system …

Unprecedented genetic variability of PFam54 paralogs among Eurasian Lyme borreliosis‐causing spirochetes

J Wülbern, L Windorfer, K Sato, M Nakao… - Ecology and …, 2024 - Wiley Online Library
Lyme borreliosis (LB) is the most common vector‐borne disease in the Northern
Hemisphere caused by spirochetes belonging to the Borrelia burgdorferi sensu lato (Bb sl) …

Resequencing and characterization of the first Corynebacterium pseudotuberculosis genome isolated from camel

EGT Gimenez, MVC Viana, T de Jesus Sousa… - PeerJ, 2024 - peerj.com
Background Corynebacterium pseudotuberculosis is a zoonotic Gram-positive bacterial
pathogen known to cause different diseases in many mammals, including lymph node …

Analysis of the Borreliaceae Pangenome Reveals a Conserved Genomic Archictecture Across Phylogenetic Scales

JE Lemieux - bioRxiv, 2024 - biorxiv.org
The Family Borreliaceae contains arthropod-borne spirochetes that cause two widespread
human diseases, Lyme disease (LD) and relapsing fever (RF). LD is a subacute …