Protein aggregation is common to dozens of diseases including prionoses, diabetes,
Parkinson's and Alzheimer's. Over the past 15 years, there has been a paradigm shift in …

Misfolding and aggregation of the proteins amyloid‐β, tau and alpha‐synuclein is the
predominant pathology underlying the neurodegenerative disorders, Alzheimer's and …

The molecular chaperones are central mediators of protein homeostasis. In that role, they
engage in widespread protein–protein interactions (PPIs) with each other and with their" …

Prefoldin is a cochaperone, present in all eukaryotes, that cooperates with the chaperonin
CCT. It is known mainly for its functional relevance in the cytoplasmic folding of actin and …

Cellular functions are largely performed by proteins. Defects in the production, folding, or
removal of proteins from the cell lead to perturbations in cellular functions that can result in …

Background Prefoldin is an evolutionarily conserved co-chaperone of the tailless complex
polypeptide 1 ring complex (TRiC)/chaperonin containing tailless complex 1 (CCT). The …

Introduction: The protein folding process is very sensitive to environmental conditions. Many
possibilities in the form of numerous pathways for this process can—if an incorrect one is …

Chaperones have long been recognized to play well defined functions such as to:(i) assist
protein folding and promote formation and maintenance of multisubunit complexes;(ii) …

The correct folding is a key process for a protein to acquire its functional structure and
conformation. Prefoldin is a well-known chaperone protein that regulates the correct folding …

Axons are the narrow, up-to-meter long cellular processes of neurons that form the
biological cables wiring our nervous system. Most axons must survive for an organism's …