Inflammation and reactive oxygen species as disease modifiers in epilepsy

G Terrone, S Balosso, A Pauletti, T Ravizza… - …, 2020 - Elsevier
Neuroinflammation and reactive oxygen and nitrogen species are rapidly induced in the
brain after acute cerebral injuries that are associated with an enhanced risk for epilepsy in …

Impact of predictive, preventive and precision medicine strategies in epilepsy

R Nabbout, M Kuchenbuch - Nature Reviews Neurology, 2020 - nature.com
Over the last decade, advances in genetics, neuroimaging and EEG have enabled the
aetiology of epilepsy to be identified earlier in the disease course than ever before. At the …

A review of seizures and epilepsy following traumatic brain injury

S Fordington, M Manford - Journal of neurology, 2020 - Springer
Traumatic brain injury (TBI) is one of the commonest presentations to emergency
departments and is associated with seizures carrying different significance at different …

Reactive glia inflammatory signaling pathways and epilepsy

P Sanz, MA Garcia-Gimeno - International journal of molecular sciences, 2020 - mdpi.com
Neuroinflammation and epilepsy are interconnected. Brain inflammation promotes neuronal
hyper-excitability and seizures, and dysregulation in the glia immune-inflammatory function …

Biomarkers of pathological dissociation: a systematic review

MI Roydeva, AATS Reinders - Neuroscience & Biobehavioral Reviews, 2021 - Elsevier
Pathological dissociation is a severe, debilitating and transdiagnostic psychiatric symptom.
This review identifies biomarkers of pathological dissociation in a transdiagnostic manner to …

Identification of clinically relevant biomarkers of epileptogenesis—a strategic roadmap

M Simonato, DV Agoston, A Brooks-Kayal… - Nature Reviews …, 2021 - nature.com
Onset of many forms of epilepsy occurs after an initial epileptogenic insult or as a result of an
identified genetic defect. Given that the precipitating insult is known, these epilepsies are, in …

Biomarkers for epileptogenesis and its treatment

J Engel Jr, A Pitkänen - Neuropharmacology, 2020 - Elsevier
There are no pharmacological interventions to prevent the development of epilepsy,
although many promising compounds have been identified in the animal laboratory. Clinical …

Epilepsy and its neurobehavioral comorbidities: insights gained from animal models

W Löscher, CE Stafstrom - Epilepsia, 2023 - Wiley Online Library
It is well established that epilepsy is associated with numerous neurobehavioral
comorbidities, with a bidirectional relationship; people with epilepsy have an increased …

Differential cortical network engagement during states of un/consciousness in humans

R Zelmann, AC Paulk, F Tian, GAB Villegas, JD Peralta… - Neuron, 2023 - cell.com
What happens in the human brain when we are unconscious? Despite substantial work, we
are still unsure which brain regions are involved and how they are impacted when …

Developing a multi-level intrusion detection system using hybrid-DBN

AA Süzen - Journal of Ambient Intelligence and Humanized …, 2021 - Springer
In this study, a hybrid deep belief network (DBN) cyber intrusion detection system was
proposed to provide a secure network by controlling network traffic in Industrial control …