In the early 1950s, Austin and Chang independently described the changes that are
required for the sperm to fertilize oocytes in vivo. These changes were originally grouped …

The transient receptor potential (TRP) superfamily consists of a large number of cation
channels that are mostly permeable to both monovalent and divalent cations. The 28 …

The transient receptor potential (TRP) protein superfamily consists of a diverse group of
cation channels that bear structural similarities to Drosophila TRP. TRP channels play …

A proper dialogue between spermatozoa and the egg is essential for conception of a new
individual in sexually reproducing animals. Ca2+ is crucial in orchestrating this unique event …

BACKGROUND Sperm hyperactivation is critical to fertilization, because it is required for
penetration of the zona pellucida. Hyperactivation may also facilitate release of sperm from …

Elevations of sperm Ca2+ seem to be responsible for an asymmetric form of motility called
hyperactivation, which is first seen near the time of fertilization. The mechanism by which …

Intracellular Ca 2+ stores play a central role in the regulation of cellular [Ca 2+] i and the
generation of complex [Ca 2+] signals such as oscillations and waves. Ca 2+ signalling is of …

Spermatogenesis, an elaborate and male-specific process in adult testes by which a number
of spermatozoa are produced constantly for male fertility, relies on spermatogonial stem …

Fertilization is the process by which haploid gametes, sperm and egg, unite to produce a
genetically distinct individual. Interest in this area has exploded in recent years. Here are …

Calcium is an essential ion which regulates sperm motility, capacitation and the acrosome
reaction (AR), three processes necessary for successful fertilization. The AR enables the …