Blindness and vision impairment are the most devastating global health problems resulting
in a substantial economic and social burden. Delivery of drug to particular parts of the …

It is generally believed that it is virtually impossible to obtain therapeutic drug concentrations
in the posterior segment of the eye after topical application of aqueous, low viscosity eye …

Ketoconazole (KET), a synthetic imidazole broad-spectrum antifungal agent, is
characterized by its poor aqueous solubility and high molecular weight, which might hamper …

Cyclodextrins (CDs) are a family of cyclic oligosaccharides, consisting of a macrocyclic ring
of glucose subunits linked by α-1, 4 glycosidic bonds. The shape of CD molecules is similar …

Eye is the most sensitive organ of the body. Designing of ocular drug delivery system is the
most challenging field for pharmaceutical scientists as less than 5% of administered drug …

Oral ketoconazole therapy is commonly associated with serious hepatotoxicity. Improving
ocular drug delivery could be sufficient to treat eye fungal infections. The purpose of this …

Purpose The aim of the present study was to develop and optimize sinomenine
hydrochloride (SIN) in situ gel for uveitis treatment. Methods Carbopol 940 was used as the …

The prevalence of chronic fundus diseases is increasing with the aging of the general
population. The treatment of these intraocular diseases relies on invasive drug delivery …

Eye is delicate organ of body whose defence mechanism restricts entry of exogenous
substances. Conventional drug delivery systems get washed off within a short period of time …

Glaucoma is a long-term eye disease associated with high intraocular pressure (IOP), which
seriously damages the eyes, causing blindness. For successful therapy, potent drugs and …