Following their exit from the thymus, T cells are endowed with potent effector functions but
must spare host tissue from harm. The fate of these cells is dictated by a series of …

Dendritic cells (DCs) are highly susceptible to extrinsic signals that modify the functions of
these crucial APCs. Maturation of DCs induced by diverse proinflammatory conditions …

Immune checkpoint blockers (ICBs) have failed in all phase III glioblastoma (GBM) trials.
Here, we show that regulatory T (Treg) cells play a key role in GBM resistance to ICBs in …

T cells possess an array of functional capabilities important for host defense against
pathogens and tumors. T cell effector functions require the T cell antigen receptor (TCR) …

A failure in immune tolerance leads to autoimmune destruction of insulin-producing β-cells,
leading to type 1 diabetes (T1D). Inhibiting autoreactive T cells and inducing regulatory T …

The NT5E (CD73) molecule represents an ecto-5′-nucleotidase expressed on the cell
surface of various cell types. Hydrolyzing extracellular adenosine monophosphate into …

The gut microbiome is the largest source of intrinsic non–self-antigens that are continuously
sensed by the immune system but typically do not elicit lymphocyte responses. CD4+ T cells …

During pregnancy, trophoblast cells sustain the maternal–fetal tolerance via expressing and
secreting various chemokines and cytokines. Our previous study revealed the expression of …

Excessive levels of proinflammatory cytokines in the CNS are associated with reduced
serotonin (5‐HT) synthesis, a neurotransmitter with diverse immune effects. In this study, we …

Pregnancy is a common immunization event, but the molecular mechanisms and
immunological consequences provoked by pregnancy remain largely unknown. We used …