1, 1, 1, 3, 3, 3-Hexafluoroisopropanol (HFIP) is a polar, strongly hydrogen bond-donating
solvent that has found numerous uses in organic synthesis due to its ability to stabilize ionic …

The precise construction of chiral molecules is a core research area in chemical science and
technology. Among the plethora of reported synthetic methods, asymmetric catalysis has …

Axial chirality widely exists in natural products, pharmaceutical compounds, and other
functional molecules; these axially chiral compounds also find wide utility as catalysts or …

Organocatalytic Reactions Enabled by N-Heterocyclic Carbenes | Chemical Reviews ACS
ACS Publications C&EN CAS Find my institution Log In Chemical Reviews ACS Publications …

N‐Heterocyclic carbene (NHC) catalysis has emerged as a powerful stratagem in organic
synthesis to construct complex molecules primarily by polarity reversal (umpolung) …

The construction of N–N axially chiral motifs is an important research topic, owing to their
wide occurrence in natural products, pharmaceuticals and chiral ligands. One efficient …

We present herein an unprecedented stereoselective synthesis of bridged biaryls with
defined axial and central chirality from readily available starting materials. This N …

Great success has been achieved in precisely constructing C–C bonds under N-heterocyclic
carbene (NHC)/Brønsted acid (BA) cooperative catalysis. However, how NHC and BA co …

Over the past decade, the catalysis of N-heterocyclic carbenes has achieved significant
advances. In this area, aldehydes, enals, and esters, are commonly employed as starting …

While N-heterocyclic carbenes (NHCs) have played an important role as Lewis-base
organocatalysts and developed recently into a full chapter of this exciting area of …