Covalent fragment approaches combine advantages of covalent binders and fragment-
based drug discovery (FBDD) for target identification and validation. Although early …

Cellular metabolism encompasses a complex array of interconnected biochemical pathways
that are required for cellular homeostasis. When dysregulated, metabolism underlies …

Targeted protein degradation relies on small molecules that induce new protein–protein
interactions between targets and the cellular protein degradation machinery. Most of these …

Mapping the ligandability or potential druggability of all proteins in the human proteome is a
central goal of mass spectrometry-based covalent chemoproteomics. Achieving this …

Covalent antibody recruiting molecules (cARMs) constitute a proximity-inducing chemical
strategy to modulate the recognition and elimination of cancer cells by the immune system …

Glioblastoma (GBM) is a malignancy dominated by the infiltration of tumor-associated
myeloid cells (TAMCs). Examination of TAMC metabolic phenotypes in mouse models and …

Covalent drug discovery has undergone a resurgence over the past two decades and
reactive cysteine profiling has emerged in parallel as a platform for ligand discovery through …

Creatine kinase (CK), as an important biochemical index of cardiac injury, is very significant
for early and accurate diagnosis of acute myocardial infarction or cardiac arrest. However …

Redox signaling, a mode of signal transduction that involves the transfer of electrons from a
nucleophilic to electrophilic molecule, has emerged as an essential regulator of …

Immunoglobulin E (IgE)‐mediated food allergy is a rapidly growing public health problem.
The interaction between allergens and IgE is at the core of the allergic response. One of the …