Blood-brain barrier dysfunction and recovery after ischemic stroke
The blood-brain barrier (BBB) plays a vital role in regulating the trafficking of fluid, solutes
and cells at the blood-brain interface and maintaining the homeostatic microenvironment of …
and cells at the blood-brain interface and maintaining the homeostatic microenvironment of …
[HTML][HTML] Intracellular transport and regulation of transcytosis across the blood–brain barrier
R Villaseñor, J Lampe, M Schwaninger… - Cellular and molecular life …, 2019 - Springer
The blood–brain barrier is a dynamic multicellular interface that regulates the transport of
molecules between the blood circulation and the brain parenchyma. Proteins and peptides …
molecules between the blood circulation and the brain parenchyma. Proteins and peptides …
[HTML][HTML] Stepwise recruitment of transcellular and paracellular pathways underlies blood-brain barrier breakdown in stroke
Brain endothelial cells form a paracellular and transcellular barrier to many blood-borne
solutes via tight junctions (TJs) and scarce endocytotic vesicles. The blood-brain barrier …
solutes via tight junctions (TJs) and scarce endocytotic vesicles. The blood-brain barrier …
[HTML][HTML] Neurodegeneration and neuro-regeneration—Alzheimer's disease and stem cell therapy
V Vasic, K Barth, MHH Schmidt - International journal of molecular …, 2019 - mdpi.com
Aging causes many changes in the human body, and is a high risk for various diseases.
Dementia, a common age-related disease, is a clinical disorder triggered by …
Dementia, a common age-related disease, is a clinical disorder triggered by …
[HTML][HTML] Dysfunction of cerebrovascular endothelial cells: prelude to vascular dementia
F Wang, Y Cao, L Ma, H Pei, WD Rausch… - Frontiers in aging …, 2018 - frontiersin.org
Vascular dementia (VaD) is the second most common type of dementia after Alzheimer's
disease (AD), characterized by progressive cognitive impairment, memory loss, and thinking …
disease (AD), characterized by progressive cognitive impairment, memory loss, and thinking …
Cerebral blood flow regulation by nitric oxide: recent advances
N Toda, K Ayajiki, T Okamura - Pharmacological reviews, 2009 - ASPET
Nitric oxide (NO) is undoubtedly quite an important intercellular messenger in cerebral and
peripheral hemodynamics. This molecule, formed by constitutive isomers of NO synthase …
peripheral hemodynamics. This molecule, formed by constitutive isomers of NO synthase …
[HTML][HTML] The pathophysiology of moyamoya disease: an update
Moyamoya disease (MMD) is a unique cerebrovascular disease characterized by the
progressive stenosis of large intracranial arteries and a hazy network of basal collaterals …
progressive stenosis of large intracranial arteries and a hazy network of basal collaterals …
Caveolae as organizers of pharmacologically relevant signal transduction molecules
Caveolae, a subset of membrane (lipid) rafts, are flask-like invaginations of the plasma
membrane that contain caveolin proteins, which serve as organizing centers for cellular …
membrane that contain caveolin proteins, which serve as organizing centers for cellular …
[HTML][HTML] Endothelial caveolin-1 regulates cerebral thrombo-inflammation in acute ischemia/reperfusion injury
X Zhang, P Gong, Y Zhao, T Wan, K Yuan, Y Xiong… - …, 2022 - thelancet.com
Background Thrombo-inflammation is an important checkpoint that orchestrates infarct
development in ischemic stroke. However, the underlying mechanism remains largely …
development in ischemic stroke. However, the underlying mechanism remains largely …
Caveolin‐1 regulates nitric oxide‐mediated matrix metalloproteinases activity and blood–brain barrier permeability in focal cerebral ischemia and reperfusion injury
J. Neurochem.(2012) 120, 147–156. Abstract The roles of caveolin‐1 (cav‐1) in regulating
blood–brain barrier (BBB) permeability are unclear yet. We previously reported that cav‐1 …
blood–brain barrier (BBB) permeability are unclear yet. We previously reported that cav‐1 …