About 15% of patients with Parkinson disease (PD) have family history and 5–10% have a
monogenic form of the disease with Mendelian inheritance. To date, at least 23 loci and 19 …

α-Synuclein is an abundant neuronal protein that is highly enriched in presynaptic nerve
terminals. Genetics and neuropathology studies link α-synuclein to Parkinson's disease (PD) …

Mutations in SNCA, the gene encoding α-synuclein (αSyn), cause familial Parkinson's
disease (PD) and aberrant αSyn is a key pathological hallmark of idiopathic PD. This α …

Almost two decades of genetic research in Parkinson's disease (PD) have remarkably
increased our knowledge regarding the genetic basis of PD with numerous genes and …

Intracellular accumulation of abnormal proteins with conformational changes is the defining
neuropathological feature of neurodegenerative diseases. The pathogenic proteins that …

Mutations in the SNCA gene, which encodes the protein α-synuclein, have been linked with
early onset Parkinson's disease. The exact nature of this association, however, is still poorly …

Background Autosomal dominant mutations in α-synuclein, TDP-43 and tau are thought to
predispose to neurodegeneration by enhancing protein aggregation. While a subset of α …

α-Synuclein (α-syn) is an intrinsically disordered protein abundantly distributed in
presynaptic terminals. Aggregation of α-syn into Lewy bodies (LB) is a molecular hallmark of …

Background Progress in genetics–particularly the advent of next‐generation sequencing
(NGS)–has enabled an unparalleled gene discovery and revealed unmatched complexity of …

Parkinson's disease (PD) is primarily a movement disorder driven by the loss of dopamine‐
producing neurons in the substantia nigra (SN). Early identification of the oxidative …