Integrator is a metazoan-specific protein complex capable of inducing termination at all
RNAPII-transcribed loci. Integrator recognizes paused, promoter-proximal RNAPII and …

In higher eukaryotes, fine-tuned activation of protein-coding genes and many non-coding
RNAs pivots around the regulated activity of RNA polymerase II (Pol II). The Integrator …

Trimethylation of histone H3 lysine 4 (H3K4me3) is associated with transcriptional start sites
and has been proposed to regulate transcription initiation,. However, redundant functions of …

Summary RNA polymerase II (RNAPII) pausing in early elongation is critical for gene
regulation. Paused RNAPII can be released into productive elongation by the kinase P-TEFb …

The elongation stage of transcription by RNA polymerase II (RNA Pol II) is central to the
regulation of gene expression in response to developmental and environmental cues in …

Downstream-of-gene (DoG) transcripts are an emerging class of noncoding RNAs.
However, it remains largely unknown how DoG RNA production is regulated and whether …

DNA replication preferentially initiates close to active transcription start sites (TSSs) in the
human genome. Transcription proceeds discontinuously with an accumulation of RNA …

A universal characteristic of eukaryotic transcription is that the promoter recruits RNA
polymerase II (RNAPII) to produce both precursor mRNAs (pre-mRNAs) and short unstable …

Transcription is the first step of gene expression and involves RNA polymerases. After
transcription initiation, RNA polymerase enters elongation followed by transcription …

The use of alternative promoters, splicing, and cleavage and polyadenylation (APA)
generates mRNA isoforms that expand the diversity and complexity of the transcriptome …