Leptin has key roles in the regulation of energy balance, body weight, metabolism, and
endocrine function. Leptin levels are undetectable or very low in patients with lipodystrophy …

Leptin is an adipocyte-secreted hormone that has been proposed to regulate energy
homeostasis as well as metabolic, reproductive, neuroendocrine, and immune functions. In …

Since its discovery as an adipocyte-secreted hormone, leptin has been found to impact food
intake, energy homeostasis, and metabolism through its effects on the central nervous …

Obesity is a worldwide epidemic, with the number of overweight and obese individuals
climbing from just over 500 million in 2008 to 1.9 billion in 2014. Type 2 diabetes (T2D) …

Glucose homeostasis is closely regulated not only by insulin, but also by leptin. Both
hormones act centrally, regulating food intake and adiposity in humans. Leptin has several …

Leptin is a pleiotropic cytokine‐like hormone that is involved in the regulation of energy
intake and expenditure, neuroendocrine function, immunity and lipid and glucose …

OBJECTIVE We prospectively examined plasma levels of leptin and soluble leptin receptor
(sOB-R), as well as their interactions with other diabetes risk factors, in relation to type 2 …

To describe our 10-year experience in treating leptin-deficient humans. Three adults and
one boy presented with childhood-onset morbid obesity, hypogonadism and family history of …

Leptin is a hormone secreted by adipocytes that regulates energy metabolism via peripheral
action on glucose synthesis and utilization as well as through central regulation of food …

Leptin (from the Greek word “lepto''meaning “thin”) is a 167-amino acid peptide hormone
encoded by the obesity (ob) gene and secreted by white adipocytes. Blood leptin …