The blood-brain barrier in aging and neurodegeneration
The blood-brain barrier (BBB) is vital for maintaining brain homeostasis by enabling an
exquisite control of exchange of compounds between the blood and the brain parenchyma …
exquisite control of exchange of compounds between the blood and the brain parenchyma …
Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function and shuttling of drugs and antibodies
The high selectivity of the human blood-brain barrier (BBB) restricts delivery of many
pharmaceuticals and therapeutic antibodies to the central nervous system. Here, we …
pharmaceuticals and therapeutic antibodies to the central nervous system. Here, we …
Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 clinical guidelines for the management of adults with major depressive disorder: section 3 …
SH Kennedy, RW Lam, RS McIntyre… - The Canadian …, 2016 - journals.sagepub.com
Background: The Canadian Network for Mood and Anxiety Treatments (CANMAT)
conducted a revision of the 2009 guidelines by updating the evidence and …
conducted a revision of the 2009 guidelines by updating the evidence and …
Blood-brain barrier regulation in psychiatric disorders
The blood-brain barrier (BBB) is a dynamic interface between the peripheral blood supply
and the cerebral parenchyma, controlling the transport of material to and from the brain …
and the cerebral parenchyma, controlling the transport of material to and from the brain …
Strategies for transporting nanoparticles across the blood–brain barrier
The existence of blood–brain barrier (BBB) hampers the effective treatment of central
nervous system (CNS) diseases. Almost all macromolecular drugs and more than 98% of …
nervous system (CNS) diseases. Almost all macromolecular drugs and more than 98% of …
Intranasal drug delivery: an efficient and non-invasive route for systemic administration: focus on opioids
S Grassin-Delyle, A Buenestado, E Naline… - Pharmacology & …, 2012 - Elsevier
Intranasal administration is a non-invasive route for drug delivery, which is widely used for
the local treatment of rhinitis or nasal polyposis. Since drugs can be absorbed into the …
the local treatment of rhinitis or nasal polyposis. Since drugs can be absorbed into the …
Human beta cells produce and release serotonin to inhibit glucagon secretion from alpha cells
In the pancreatic islet, serotonin is an autocrine signal increasing beta cell mass during
metabolic challenges such as those associated with pregnancy or high-fat diet. It is still …
metabolic challenges such as those associated with pregnancy or high-fat diet. It is still …
[HTML][HTML] Sex differences in the blood–brain barrier: implications for mental health
Prevalence of mental disorders, including major depressive disorder (MDD), bipolar
disorder (BD) and schizophrenia (SZ) are increasing at alarming rates in our societies …
disorder (BD) and schizophrenia (SZ) are increasing at alarming rates in our societies …
Design and application in delivery system of intranasal antidepressants
J Xu, J Tao, J Wang - Frontiers in Bioengineering and Biotechnology, 2020 - frontiersin.org
One of the major reasons why depressed patients fail their treatment course is the existence
of the blood-brain barrier (BBB), which prevents drugs from being delivered to the central …
of the blood-brain barrier (BBB), which prevents drugs from being delivered to the central …
Clinical implementation of pharmacogenetic decision support tools for antidepressant drug prescribing
The accrual and analysis of genomic sequencing data have identified specific genetic
variants that are associated with major depressive disorder. Moreover, substantial …
variants that are associated with major depressive disorder. Moreover, substantial …