RNAi-based therapeutics and tumor targeted delivery in cancer
Over the past decade, non-coding RNA-based therapeutics have proven as a great potential
for the development of targeted therapies for cancer and other diseases. The discovery of …
for the development of targeted therapies for cancer and other diseases. The discovery of …
Fundamentals of siRNA and miRNA therapeutics and a review of targeted nanoparticle delivery systems in breast cancer
Gene silencing via RNA interference (RNAi) is rapidly evolving as a personalized approach
to cancer treatment. The effector molecules—small interfering RNAs (siRNAs) and …
to cancer treatment. The effector molecules—small interfering RNAs (siRNAs) and …
[PDF][PDF] Fusogenic reactive oxygen species triggered charge‐reversal vector for effective gene delivery
DOI: 10.1002/adma. 201504288 a reactive oxygen species (ROS)-labile charge-reversal
polymer, poly [(2-acryloyl) ethyl (p-boronic acid benzyl) diethylammonium bromide](B …
polymer, poly [(2-acryloyl) ethyl (p-boronic acid benzyl) diethylammonium bromide](B …
Efficient nanocarriers of siRNA therapeutics for cancer treatment
MA Subhan, VP Torchilin - Translational Research, 2019 - Elsevier
Nanocarriers as drug delivery systems are promising and becoming popular, especially for
cancer treatment. In addition to improving the pharmacokinetics of poorly soluble …
cancer treatment. In addition to improving the pharmacokinetics of poorly soluble …
Nano-scale delivery systems for siRNA delivery in cancer therapy: New era of gene therapy empowered by nanotechnology
N Ebrahimi, MS Manavi, A Nazari, A Momayezi… - Environmental …, 2023 - Elsevier
RNA interference (RNAi) is a unique treatment approach used to decrease a disease's
excessive gene expression, including cancer. SiRNAs may find and destroy homologous …
excessive gene expression, including cancer. SiRNAs may find and destroy homologous …
Design of nanocarriers for nanoscale drug delivery to enhance cancer treatment using hybrid polymer and lipid building blocks
Polymer–lipid hybrid nanoparticles (PLN) are an emerging nanocarrier platform made from
building blocks of polymers and lipids. PLN integrate the advantages of biomimetic lipid …
building blocks of polymers and lipids. PLN integrate the advantages of biomimetic lipid …
Improved nucleic acid therapy with advanced nanoscale biotechnology
Y Weng, Q Huang, C Li, Y Yang, X Wang, J Yu… - … Therapy-Nucleic Acids, 2020 - cell.com
Due to a series of systemic and intracellular obstacles in nucleic acid (NA) therapy, including
fast degradation in blood, renal clearance, poor cellular uptake, and inefficient endosomal …
fast degradation in blood, renal clearance, poor cellular uptake, and inefficient endosomal …
Multifunctional polymeric micellar nanomedicine in the diagnosis and treatment of cancer
N Raval, R Maheshwari, H Shukla, K Kalia… - Materials Science and …, 2021 - Elsevier
Polymeric micelles are a prevalent topic of research for the past decade, especially
concerning their fitting ability to deliver drug and diagnostic agents. This delivery system …
concerning their fitting ability to deliver drug and diagnostic agents. This delivery system …
Synthetic approaches for nucleic acid delivery: choosing the right carriers
The discovery of the genetic roots of various human diseases has motivated the exploration
of different exogenous nucleic acids as therapeutic agents to treat these genetic disorders …
of different exogenous nucleic acids as therapeutic agents to treat these genetic disorders …
Micelle-like nanoparticles as carriers for DNA and siRNA
G Navarro, J Pan, VP Torchilin - Molecular pharmaceutics, 2015 - ACS Publications
Gene therapy represents a potential efficient approach of disease prevention and therapy.
However, due to their poor in vivo stability, gene molecules need to be associated with …
However, due to their poor in vivo stability, gene molecules need to be associated with …