Mechanisms of leptin action and leptin resistance
The adipose tissue–derived hormone leptin acts via its receptor (LRb) in the brain to
regulate energy balance and neuroendocrine function. LRb signaling via STAT3 and a …
regulate energy balance and neuroendocrine function. LRb signaling via STAT3 and a …
Models of body weight and fatness regulation
JR Speakman, KD Hall - Philosophical Transactions of …, 2023 - royalsocietypublishing.org
Body weight and fatness appear to be regulated phenomena. Several different theoretical
models are available to capture the essence of this idea. These include the set-point …
models are available to capture the essence of this idea. These include the set-point …
Leptin resistance: a prediposing factor for diet-induced obesity
PJ Scarpace, Y Zhang - American Journal of Physiology …, 2009 - journals.physiology.org
Obesity is a resilient and complex chronic disease. One potential causative factor in the
obesity syndrome is leptin resistance. Leptin behaves as a potent anorexic and energy …
obesity syndrome is leptin resistance. Leptin behaves as a potent anorexic and energy …
[HTML][HTML] Leptin signaling in brain: a link between nutrition and cognition?
CD Morrison - Biochimica et biophysica acta (BBA)-molecular basis of …, 2009 - Elsevier
Leptin is a protein hormone that acts within the hypothalamus to suppress food intake and
decrease body adiposity, but it is increasingly clear that the hypothalamus is not the only site …
decrease body adiposity, but it is increasingly clear that the hypothalamus is not the only site …
The evolution of body fatness: trading off disease and predation risk
JR Speakman - Journal of Experimental Biology, 2018 - journals.biologists.com
Human obesity has a large genetic component, yet has many serious negative
consequences. How this state of affairs has evolved has generated wide debate. The thrifty …
consequences. How this state of affairs has evolved has generated wide debate. The thrifty …
The contribution of animal models to the study of obesity
Obesity results from prolonged imbalance of energy intake and energy expenditure. Animal
models have provided a fundamental contribution to the historical development of …
models have provided a fundamental contribution to the historical development of …
Neuroendocrine mechanisms of change in food intake during pregnancy: a potential role for brain oxytocin
AJ Douglas, LE Johnstone, G Leng - Physiology & behavior, 2007 - Elsevier
During pregnancy body weight, and particularly adiposity, increase, due to hyperphagia
rather than decreased energy metabolism. These physiological adaptations provide the …
rather than decreased energy metabolism. These physiological adaptations provide the …
Endocrine mechanisms of seasonal adaptation in small mammals: from early results to present understanding
F Scherbarth, S Steinlechner - Journal of Comparative Physiology B, 2010 - Springer
Seasonal adaptation is widespread among mammals of temperate and polar latitudes. The
changes in physiology, morphology and behaviour are controlled by the …
changes in physiology, morphology and behaviour are controlled by the …
Physiological models of leptin resistance
A Tups - Journal of neuroendocrinology, 2009 - Wiley Online Library
In common forms of obesity, animals and humans become leptin resistant associated with
impaired regulation of energy homeostasis. Over the last decade, significant advances in …
impaired regulation of energy homeostasis. Over the last decade, significant advances in …
[HTML][HTML] Leptin and its cardiovascular effects: Focus on angiogenesis
Z Tahergorabi, M Khazaei - Advanced biomedical research, 2015 - journals.lww.com
Leptin is an endocrine hormone synthesized by adipocytes. It plays a key role in the energy
homeostasis in central and peripheral tissues and has additional roles are attributed to it …
homeostasis in central and peripheral tissues and has additional roles are attributed to it …