The adipose tissue–derived hormone leptin acts via its receptor (LRb) in the brain to
regulate energy balance and neuroendocrine function. LRb signaling via STAT3 and a …

Body weight and fatness appear to be regulated phenomena. Several different theoretical
models are available to capture the essence of this idea. These include the set-point …

Obesity is a resilient and complex chronic disease. One potential causative factor in the
obesity syndrome is leptin resistance. Leptin behaves as a potent anorexic and energy …

Leptin is a protein hormone that acts within the hypothalamus to suppress food intake and
decrease body adiposity, but it is increasingly clear that the hypothalamus is not the only site …

Human obesity has a large genetic component, yet has many serious negative
consequences. How this state of affairs has evolved has generated wide debate. The thrifty …

Obesity results from prolonged imbalance of energy intake and energy expenditure. Animal
models have provided a fundamental contribution to the historical development of …

During pregnancy body weight, and particularly adiposity, increase, due to hyperphagia
rather than decreased energy metabolism. These physiological adaptations provide the …

Seasonal adaptation is widespread among mammals of temperate and polar latitudes. The
changes in physiology, morphology and behaviour are controlled by the …

In common forms of obesity, animals and humans become leptin resistant associated with
impaired regulation of energy homeostasis. Over the last decade, significant advances in …

Leptin is an endocrine hormone synthesized by adipocytes. It plays a key role in the energy
homeostasis in central and peripheral tissues and has additional roles are attributed to it …