The activation of a substrate by a chiral catalyst is now regarded as one of the most powerful
strategies that can be employed in the art of asymmetric synthesis. 1 The development of …

In his seminal work, 1 Rolf Huisgen defined 1, 3-dipolar cycloadditions as “1, 3-Dipole, abc,
must be defined, such that atom a posseses an electron sextet, that is, an incomplete …

Azomethine imines are considered 1, 3-dipoles of the aza-allyl type which are transient
intermediates and should be generated in situ but can also be stable and isolable …

A protocol for the highly enantioselective synthesis of 9‐substituted tetrahydroxanthenones
by means of asymmetric Brønsted acid catalysis has been developed. A chiral binol‐based …

Figure 73: The proposed catalyst/substrate interaction shown in Figure 73 corresponds to
the related sulfoxidation catalyzed by chiral phosphoric acid PA 5 (ref 133). Please note that …

A new type of chiral super Brønsted C–H acids, BINOL-derived phosphoryl bis
((trifluoromethyl) sulfonyl) methanes (BPTMs), were developed. As compared to widely …

Beyond a doubt organocatalysis belongs to the most exciting and innovative chapters of
organic chemistry today. Organocatalysis has emerged not only as a complement to metal …

Radical cascade cyclization of β, γ‐unsaturated hydrazones/oximes has recently emerged
as an efficient and powerful protocol for the construction of diverse and valuable …

The palladium‐catalyzed asymmetric carboamination reaction is one of the most significant
transformations in organic chemistry. Herein, we report the first palladium‐catalyzed …

A novel photocatalytic hydrazonyl radical-mediated radical cyclization/allylation cascade
reaction of β, γ-unsaturated hydrazones is developed using allyl sulfones and Morita–Baylis …