Chronic obstructive pulmonary disease (COPD) is emphysema and/or chronic bronchitis
characterised by long-term breathing problems and poor airflow. The prevalence of COPD …

Chronic obstructive pulmonary disease (COPD) is associated with chronic inflammation
affecting predominantly the lung parenchyma and peripheral airways that results in largely …

Pulmonary defense against environmental injury depends on airway mucus, which traps
inhaled toxins that are then cleared from the lungs by ciliary beating and cough. This review …

Chronic obstructive pulmonary disease (COPD) is associated with chronic inflammation of
the peripheral airways and lung parenchyma, which leads to progressive obstruction of the …

Numerous epidemiological studies have consistently linked the presence of chronic
obstructive pulmonary disease (COPD) to the development of lung cancer, independently of …

In asthma, airflow obstruction is thought to result primarily from inflammation-triggered
airway smooth muscle (ASM) contraction. However, anti-inflammatory and smooth muscle …

The respiratory tract surface is protected from inhaled pathogens by a secreted layer of
mucus rich in mucin glycoproteins. Abnormal mucus accumulation is a cardinal feature of …

The lung is a delicate organ with a large surface area that is continuously exposed to the
external environment, and is therefore highly vulnerable to exogenous sources of oxidative …

Airway mucus in cystic fibrosis (CF) is highly elastic, but the mechanism behind this
pathology is unclear. We hypothesized that the biophysical properties of CF mucus are …

Both chronic obstructive pulmonary disease (COPD) and lung cancer are major causes of
death worldwide. In most cases this reflects cigarette smoke exposure which is able to …