Platelets are a uniquely mammalian physiologic feature. As the only non-marine vertebrates
to experience menopause, humans have a substantial post-reproductive lifespan and are …

Protein phosphorylation is a crucial regulatory mechanism in cell signaling, acting as a
molecular switch that modulates protein function. Catalyzed by protein kinases and reversed …

Background Oxidative stress contributes to thrombosis in atherosclerosis, inflammation,
infection, aging, and malignancy. Oxidant-induced cysteine modifications, including …

Intravital microscopy is a powerful tool to study thrombosis in real time. The kinetics of
thrombus formation and progression in vivo is studied after inflicting damage to the …

Vertebrate lonesome kinase (VLK) is the only known extracellular tyrosine kinase, but its
physiological functions are largely unknown. We show that VLK is highly expressed in …

Vertebrate lonesome kinase (VLK) is the only known secreted tyrosine kinase and
responsible for the phosphorylation of a broad range of secretory pathway-resident and …

随着科研技术的不断革新进步以及科研工作的深入开展, 输血医学的内容也在不断得到更新和
补充. 本文就2021—2022 年度输血医学研究进展进行简要概述, 主要包含血液不同成分的作用 …

Vertebrate lonesome kinase (Vlk) is a secreted tyrosine kinase important for normal
skeletogenesis during embryonic development. Vlk null mice (Vlk−/−) are born with severe …

In this issue of Blood, Revollo et al 1 expand our understanding of primary hemostasis by
demonstrating the crucial role of vertebrate lonesome kinase (VLK; PKDCC) in platelet …

Platelets are a uniquely mammalian physiologic attribute. As the only non-marine vertebrate
class to experience menopause, humans have a substantial post-reproductive lifespan and …