Reperfusion is mandatory to salvage ischemic myocardium from infarction, but reperfusion
per se contributes to injury and ultimate infarct size. Therefore, cardioprotection beyond that …

Abstract Sphingosine-1-phosphate (S1P) is a signaling lipid, synthetized by sphingosine
kinases (SPHK1 and SPHK2), that affects cardiovascular function in various ways. S1P …

Sphingolipids are a structural component of the cell membrane, derived from sphingosine,
an amino alcohol. Its sphingoid base undergoes various types of enzymatic transformations …

It has been documented that Ca 2+ overload and increased production of reactive oxygen
species play a significant role in reperfusion injury (RI) of cardiomyocytes …

Lowered high-density lipoprotein (HDL) cholesterol has been reported in major depressive
disorder, bipolar disorder, first episode of psychosis, and schizophrenia. HDL, its major …

G protein-coupled receptors (GPCRs) are cell surface receptors that for many years have
been considered to function exclusively at the plasma membrane, where they bind to …

Melatonin protects the heart against myocardial ischemia/reperfusion injury via the
activation of the survivor activating factor enhancement (SAFE) pathway which involves …

In this meeting report, particularly addressing the topic of protection of the cardiovascular
system from ischemia/reperfusion injury, highlights are presented that relate to conditioning …

Cardiovascular diseases (CVD) are the leading cause of death, chronic illness and disability
in Western countries. The most common cause of CVD derives from the harmful effects of …

Cardiovascular diseases (CVDs) are the leading cause of death globally and the number of
cardiovascular patients, which is estimated to be over 30 million in 2018, represent a …