[HTML][HTML] Recent developments on PET radiotracers for TSPO and their applications in neuroimaging
The 18 kDa translocator protein (TSPO), previously known as the peripheral
benzodiazepine receptor, is predominately localized to the outer mitochondrial membrane in …
benzodiazepine receptor, is predominately localized to the outer mitochondrial membrane in …
Recent progress in the development of TSPO PET ligands for neuroinflammation imaging in neurological diseases
MM Alam, J Lee, SY Lee - Nuclear medicine and molecular imaging, 2017 - Springer
Neuroinflammation is heavily associated with various neurological diseases including
Alzheimer's disease, Parkinson's disease, multiple sclerosis, and stroke. It is strongly …
Alzheimer's disease, Parkinson's disease, multiple sclerosis, and stroke. It is strongly …
The 18-kDa translocator protein PET tracers as a diagnostic marker for neuroinflammation: development and current standing
Translocator protein (TSPO, 18 kDa) is an evolutionary, well-preserved, and tryptophan-rich
169-amino-acid protein which localizes on the contact sites between the outer and inner …
169-amino-acid protein which localizes on the contact sites between the outer and inner …
18F-Radiolabeled Translocator Protein (TSPO) PET Tracers: Recent Development of TSPO Radioligands and Their Application to PET Study
Translocator protein 18 kDa (TSPO) is a transmembrane protein in the mitochondrial
membrane, which has been identified as a peripheral benzodiazepine receptor. TSPO is …
membrane, which has been identified as a peripheral benzodiazepine receptor. TSPO is …
An update into the medicinal chemistry of translocator protein (TSPO) ligands
E Barresi, M Robello, B Costa, E Da Pozzo… - European Journal of …, 2021 - Elsevier
Abstract The Translocator Protein 18 kDa (TSPO) has been discovered in 1977 as an
alternative binding site for the benzodiazepine diazepam. It is an evolutionary well …
alternative binding site for the benzodiazepine diazepam. It is an evolutionary well …
Tracking neuroinflammation in Alzheimer's disease: the role of positron emission tomography imaging
Alzheimer's disease (AD) has been reconceptualized as a dynamic pathophysiological
process, where the accumulation of amyloid-beta (Aβ) is thought to trigger a cascade of …
process, where the accumulation of amyloid-beta (Aβ) is thought to trigger a cascade of …
[HTML][HTML] Imaging of neuroinflammation in Alzheimer's disease, multiple sclerosis and stroke: Recent developments in positron emission tomography
B Janssen, DJ Vugts, U Funke, GT Molenaar… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Neuroinflammation is thought to play a pivotal role in many diseases affecting the brain,
including Alzheimer's disease, multiple sclerosis and stroke. Neuroinflammation is …
including Alzheimer's disease, multiple sclerosis and stroke. Neuroinflammation is …
Radiosynthesis and characterization of [18F]BS224: a next-generation TSPO PET ligand insensitive to the rs6971 polymorphism
SH Lee, N Denora, V Laquintana… - European Journal of …, 2021 - Springer
Abstract Purpose Translocator protein 18-kDa (TSPO) positron emission tomography (PET)
is a valuable tool to detect neuroinflammed areas in a broad spectrum of neurodegenerative …
is a valuable tool to detect neuroinflammed areas in a broad spectrum of neurodegenerative …
[HTML][HTML] Essential principles and recent progress in the development of TSPO PET ligands for neuroinflammation imaging
M Viviano, E Barresi, FG Siméon, B Costa… - Current medicinal …, 2022 - ncbi.nlm.nih.gov
The translocator protein 18kDa (TSPO) is expressed in the outer mitochondrial membrane
and is implicated in several functions, including cholesterol transport and steroidogenesis …
and is implicated in several functions, including cholesterol transport and steroidogenesis …
A Facile Radiolabeling of [18F]FDPA via Spirocyclic Iodonium Ylides: Preliminary PET Imaging Studies in Preclinical Models of Neuroinflammation
A suitable TSPO PET ligand may visualize and quantify neuroinflammation in a living brain.
Herein we report a 18F-ligand,[18 F] 2 ([18F] FDPA), is radiolabeled in high yield and high …
Herein we report a 18F-ligand,[18 F] 2 ([18F] FDPA), is radiolabeled in high yield and high …