Eukaryotic cell membranes: structure, composition, research methods and computational modelling

A Zhukov, V Popov - International Journal of Molecular Sciences, 2023 - mdpi.com
This paper deals with the problems encountered in the study of eukaryotic cell membranes.
A discussion on the structure and composition of membranes, lateral heterogeneity of …

Chromatin reprogramming and bone regeneration in vitro and in vivo via the microtopography-induced constriction of cell nuclei

X Wang, V Agrawal, CL Dunton, Y Liu… - Nature biomedical …, 2023 - nature.com
Topographical cues on cells can, through contact guidance, alter cellular plasticity and
accelerate the regeneration of cultured tissue. Here we show how changes in the nuclear …

Depletion of lamins B1 and B2 promotes chromatin mobility and induces differential gene expression by a mesoscale-motion-dependent mechanism

EM Pujadas Liwag, X Wei, N Acosta, LM Carter, J Yang… - Genome biology, 2024 - Springer
Background B-type lamins are critical nuclear envelope proteins that interact with the three-
dimensional genomic architecture. However, identifying the direct roles of B-lamins on …

Label-free dynamic imaging of chromatin in live cell nuclei by high-speed scattering-based interference microscopy

YT Hsiao, CN Tsai, TH Chen, CL Hsieh - ACS nano, 2021 - ACS Publications
Chromatin is a DNA–protein complex that is densely packed in the cell nucleus. The
nanoscale chromatin compaction plays critical roles in the modulation of cell nuclear …

Disordered chromatin packing regulates phenotypic plasticity

RKA Virk, W Wu, LM Almassalha, GM Bauer, Y Li… - Science …, 2020 - science.org
Three-dimensional supranucleosomal chromatin packing plays a profound role in
modulating gene expression by regulating transcription reactions through mechanisms such …

Dynamic “molecular portraits” of biomembranes drawn by their lateral nanoscale inhomogeneities

RG Efremov - International Journal of Molecular Sciences, 2021 - mdpi.com
To date, it has been reliably shown that the lipid bilayer/water interface can be thoroughly
characterized by a sophisticated so-called “dynamic molecular portrait”. The latter reflects a …

Probing chromatin condensation dynamics in live cells using interferometric scattering correlation spectroscopy

YT Hsiao, IH Liao, BK Wu, HPC Chu… - Communications …, 2024 - nature.com
Chromatin organization and dynamics play important roles in governing the regulation of
nuclear processes of biological cells. However, due to the constant diffusive motion of …

Molecularly specific and functional live cell imaging by label-free interference microscopy

YT Hsiao, CN Tsai, CY Cheng, CL Hsieh - ACS Photonics, 2022 - ACS Publications
Optical interference microscopy is a powerful bioimaging technique by measuring the
complex light fields associated with the specimen. Nowadays, the state-of-the-art …

Depletion of lamins B1 and B2 alters chromatin mobility and induces differential gene expression by a mesoscale-motion dependent mechanism

EM Pujadas, X Wei, N Acosta, L Carter, J Yang… - bioRxiv, 2023 - biorxiv.org
ABSTRACT BACKGROUND B-type lamins are critical nuclear envelope proteins that
interact with the 3D genomic architecture. However, identifying the direct roles of B-lamins …

Characterization of nanosensitive multifractality in submicron scale tissue morphology and its alteration in tumor progression

N Das, S Alexandrov, KE Gilligan… - … of biomedical optics, 2021 - spiedigitallibrary.org
Significance: Assessment of disease using optical coherence tomography is an actively
investigated problem, owing to many unresolved challenges in early disease detection …