Insulin-degrading enzyme (IDE) is a highly conserved and ubiquitously expressed
metalloprotease that degrades insulin and several other intermediate-size peptides. For …

Hepatic insulin clearance, a physiological process that in response to nutritional cues
clears~ 50–80% of circulating insulin, is emerging as an important factor in our …

More than seven decades have passed since the discovery of a proteolytic activity within
crude tissue extracts that would become known as insulin-degrading enzyme (IDE) …

Amylin, also known as islet amyloid polypeptide (IAPP), is a metabolic homeostasis-related
hormone that is produced and released by the β cells of the pancreas, the same cells that …

Type 2 Diabetes and Alzheimer's Disease share many common features, including one
examined in this thesis: the build-up of proteins into toxic plaque in vital organs. The thesis …

Calcitonin gene-related peptide (CGRP) is a neuromodulatory peptide that is highly
expressed in the nervous system. It is involved in several physiological and …