Role of the NLRP3 inflammasome in cancer
Inflammasomes are large intracellular multi-protein signalling complexes that are formed in
the cytosolic compartment as an inflammatory immune response to endogenous danger …
the cytosolic compartment as an inflammatory immune response to endogenous danger …
Animal models to study acute and chronic intestinal inflammation in mammals
JA Jiminez, TC Uwiera, G Douglas Inglis, RRE Uwiera - Gut pathogens, 2015 - Springer
Acute and chronic inflammatory diseases of the intestine impart a significant and negative
impact on the health and well-being of human and non-human mammalian animals …
impact on the health and well-being of human and non-human mammalian animals …
Metagenomic biomarker discovery and explanation
This study describes and validates a new method for metagenomic biomarker discovery by
way of class comparison, tests of biological consistency and effect size estimation. This …
way of class comparison, tests of biological consistency and effect size estimation. This …
Acute dextran sulfate sodium (DSS)‐induced colitis promotes gut microbial dysbiosis in mice
The most widely used and characterized experimental model of ulcerative colitis (UC) is the
epithelial erosion, dextran sulfate sodium (DSS)‐induced colitis, which is developed by …
epithelial erosion, dextran sulfate sodium (DSS)‐induced colitis, which is developed by …
[HTML][HTML] The impact of the microbiota on the pathogenesis of IBD: lessons from mouse infection models
S Nell, S Suerbaum, C Josenhans - Nature Reviews Microbiology, 2010 - nature.com
Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is a
major human health problem. The bacteria that live in the gut play an important part in the …
major human health problem. The bacteria that live in the gut play an important part in the …
Nitric oxide in inflammatory bowel disease: a universal messenger in an unsolved puzzle
In recent years, nitric oxide (NO), a gas previously considered to be a potentially toxic
chemical, has been established as a diffusible universal messenger that mediates cell–cell …
chemical, has been established as a diffusible universal messenger that mediates cell–cell …
Animal models of inflammatory bowel disease: a review
Inflammatory bowel disease (IBD) represents a group of idiopathic chronic inflammatory
intestinal conditions associated with various areas of the GI tract, including two types of …
intestinal conditions associated with various areas of the GI tract, including two types of …
IL-22 deficiency alters colonic microbiota to be transmissible and colitogenic
IL-22 is a good candidate to play a critical role in regulating gut microbiota because it is an
important inducer of antimicrobial peptides and mucins in the gut. However, whether IL-22 …
important inducer of antimicrobial peptides and mucins in the gut. However, whether IL-22 …
The Nlrp3 inflammasome: contributions to intestinal homeostasis
Inflammatory bowel diseases (IBD) such as Crohn's disease and ulcerative colitis constitute
a major health problem in developed countries. Moreover, IBD predisposes to the …
a major health problem in developed countries. Moreover, IBD predisposes to the …
Gram-negative bacteria aggravate murine small intestinal Th1-type immunopathology following oral infection with Toxoplasma gondii
MM Heimesaat, S Bereswill, A Fischer… - The Journal of …, 2006 - journals.aai.org
Oral infection of susceptible mice with Toxoplasma gondii results in Th1-type
immunopathology in the ileum. We investigated gut flora changes during ileitis and …
immunopathology in the ileum. We investigated gut flora changes during ileitis and …