Role of the NLRP3 inflammasome in cancer

M Moossavi, N Parsamanesh, A Bahrami, SL Atkin… - Molecular cancer, 2018 - Springer
Inflammasomes are large intracellular multi-protein signalling complexes that are formed in
the cytosolic compartment as an inflammatory immune response to endogenous danger …

Animal models to study acute and chronic intestinal inflammation in mammals

JA Jiminez, TC Uwiera, G Douglas Inglis, RRE Uwiera - Gut pathogens, 2015 - Springer
Acute and chronic inflammatory diseases of the intestine impart a significant and negative
impact on the health and well-being of human and non-human mammalian animals …

Metagenomic biomarker discovery and explanation

N Segata, J Izard, L Waldron, D Gevers, L Miropolsky… - Genome biology, 2011 - Springer
This study describes and validates a new method for metagenomic biomarker discovery by
way of class comparison, tests of biological consistency and effect size estimation. This …

Acute dextran sulfate sodium (DSS)‐induced colitis promotes gut microbial dysbiosis in mice

PM Munyaka, MF Rabbi, E Khafipour… - Journal of basic …, 2016 - Wiley Online Library
The most widely used and characterized experimental model of ulcerative colitis (UC) is the
epithelial erosion, dextran sulfate sodium (DSS)‐induced colitis, which is developed by …

[HTML][HTML] The impact of the microbiota on the pathogenesis of IBD: lessons from mouse infection models

S Nell, S Suerbaum, C Josenhans - Nature Reviews Microbiology, 2010 - nature.com
Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is a
major human health problem. The bacteria that live in the gut play an important part in the …

Nitric oxide in inflammatory bowel disease: a universal messenger in an unsolved puzzle

G Kolios, V Valatas, SG Ward - Immunology, 2004 - Wiley Online Library
In recent years, nitric oxide (NO), a gas previously considered to be a potentially toxic
chemical, has been established as a diffusible universal messenger that mediates cell–cell …

Animal models of inflammatory bowel disease: a review

N Goyal, A Rana, A Ahlawat, KRV Bijjem… - Inflammopharmacology, 2014 - Springer
Inflammatory bowel disease (IBD) represents a group of idiopathic chronic inflammatory
intestinal conditions associated with various areas of the GI tract, including two types of …

IL-22 deficiency alters colonic microbiota to be transmissible and colitogenic

LA Zenewicz, X Yin, G Wang, E Elinav… - The Journal of …, 2013 - journals.aai.org
IL-22 is a good candidate to play a critical role in regulating gut microbiota because it is an
important inducer of antimicrobial peptides and mucins in the gut. However, whether IL-22 …

The Nlrp3 inflammasome: contributions to intestinal homeostasis

MH Zaki, M Lamkanfi, TD Kanneganti - Trends in immunology, 2011 - cell.com
Inflammatory bowel diseases (IBD) such as Crohn's disease and ulcerative colitis constitute
a major health problem in developed countries. Moreover, IBD predisposes to the …

Gram-negative bacteria aggravate murine small intestinal Th1-type immunopathology following oral infection with Toxoplasma gondii

MM Heimesaat, S Bereswill, A Fischer… - The Journal of …, 2006 - journals.aai.org
Oral infection of susceptible mice with Toxoplasma gondii results in Th1-type
immunopathology in the ileum. We investigated gut flora changes during ileitis and …