Optogenetic techniques have been developed to allow control over the activity of selected
cells within a highly heterogeneous tissue, using a combination of genetic engineering and …

Despite major advancements in cardiovascular medicine, sudden cardiac death (SCD)
continues to be an enormous medical and societal challenge, claiming millions of lives …

The electromechanical function of the heart involves complex, coordinated activity over time
and space. Life-threatening cardiac arrhythmias arise from asynchrony in these space–time …

Small animals support a wide range of pathological phenotypes and genotypes as versatile,
affordable models for pathogenesis of cardiovascular diseases and for exploration of …

Conduction disorders and arrhythmias remain difficult to treat and are increasingly prevalent
owing to the increasing age and body mass of the general population, because both are risk …

Optogenetics is an elegant approach of precisely controlling and monitoring the biological
functions of a cell, group of cells, tissues, or organs with high temporal and spatial resolution …

The enhancement of insulin secretion and of the proliferation of pancreatic β cells are
promising therapeutic options for diabetes. Signals from the vagal nerve regulate both …

Aims Current treatments of ventricular arrhythmias rely on modulation of cardiac electrical
function through drugs, ablation or electroshocks, which are all non-biological and rather …

Optogenetic techniques permit studies of excitable tissue through genetically expressed
light-gated microbial channels or pumps permitting transmembrane ion movement. Light …

Background: Studies have shown that left stellate ganglion (LSG) suppression protects
against ventricular arrhythmias (VAs). Optogenetics is a novel technique to reversibly …