Treatment of cancer with antipsychotic medications: Pushing the boundaries of schizophrenia and cancer
JS Brown - Neuroscience & Biobehavioral Reviews, 2022 - Elsevier
Over a century ago, the phenothiazine dye, methylene blue, was discovered to have both
antipsychotic and anti-cancer effects. In the 20th-century, the first phenothiazine …
antipsychotic and anti-cancer effects. In the 20th-century, the first phenothiazine …
[PDF][PDF] Circuit-wide transcriptional profiling reveals brain region-specific gene networks regulating depression susceptibility
Depression is a complex, heterogeneous disorder and a leading contributor to the global
burden of disease. Most previous research has focused on individual brain regions and …
burden of disease. Most previous research has focused on individual brain regions and …
Genetic correlations among psychiatric and immune‐related phenotypes based on genome‐wide association data
Individuals with psychiatric disorders have elevated rates of autoimmune comorbidity and
altered immune signaling. It is unclear whether these altered immunological states have a …
altered immune signaling. It is unclear whether these altered immunological states have a …
Stress resilience is promoted by a Zfp189-driven transcriptional network in prefrontal cortex
ZS Lorsch, PJ Hamilton, A Ramakrishnan… - Nature …, 2019 - nature.com
Understanding the transcriptional changes that are engaged in stress resilience may reveal
novel antidepressant targets. Here we use gene co-expression analysis of RNA-sequencing …
novel antidepressant targets. Here we use gene co-expression analysis of RNA-sequencing …
[HTML][HTML] Contribution of induced pluripotent stem cell technologies to the understanding of cellular phenotypes in schizophrenia
S Balan, M Toyoshima, T Yoshikawa - Neurobiology of disease, 2019 - Elsevier
Schizophrenia is one of the leading causes of disability among mental disorders,
contributing to a substantial socioeconomic burden. Our understanding of the mechanisms …
contributing to a substantial socioeconomic burden. Our understanding of the mechanisms …
RNAseq analyses identify tumor necrosis factor-mediated inflammation as a major abnormality in ALS spinal cord
DG Brohawn, LC O'Brien, JP Bennett Jr - PloS one, 2016 - journals.plos.org
ALS is a rapidly progressive, devastating neurodegenerative illness of adults that produces
disabling weakness and spasticity arising from death of lower and upper motor neurons. No …
disabling weakness and spasticity arising from death of lower and upper motor neurons. No …
Whole-transcriptome analysis delineates the human placenta gene network and its associations with fetal growth
Background The placenta is the principal organ regulating intrauterine growth and
development, performing critical functions on behalf of the developing fetus. The delineation …
development, performing critical functions on behalf of the developing fetus. The delineation …
Comprehensive analysis of diabetic nephropathy expression profile based on weighted gene co-expression network analysis algorithm
Background Diabetic nephropathy (DN) is the major complication of diabetes mellitus, and
leading cause of end-stage renal disease. The underlying molecular mechanism of DN is …
leading cause of end-stage renal disease. The underlying molecular mechanism of DN is …
Comprehensive analysis of omics data identifies relevant gene networks for Attention-Deficit/Hyperactivity Disorder (ADHD)
J Cabana-Domínguez, M Soler Artigas… - Translational …, 2022 - nature.com
Attention-deficit/hyperactivity disorder (ADHD) is a highly prevalent neurodevelopmental
disorder that results from the interaction of both genetic and environmental risk factors …
disorder that results from the interaction of both genetic and environmental risk factors …
A missense variant in NDUFA6 confers schizophrenia risk by affecting YY1 binding and NAGA expression
Y Li, C Ma, W Li, Y Yang, X Li, J Liu, J Wang, S Li… - Molecular …, 2021 - nature.com
Genome-wide association studies (GWASs) have revealed that genetic variants at the
22q13. 2 risk locus were robustly associated with schizophrenia. However, the causal …
22q13. 2 risk locus were robustly associated with schizophrenia. However, the causal …