Viruses survive often harsh host environments, yet we know little about the strategies they
utilize to adapt and subsist given their limited genomic resources. We are beginning to …

There is an urgent need for antiviral agents that treat severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection. We screened a library of 1900 clinically safe drugs …

Defective viral genomes (DVGs) are generated during viral replication and are unable to
carry out a full replication cycle unless coinfected with a full-length virus. DVGs are produced …

The RNAi pathway confers antiviral immunity in insects. Virus-specific siRNA responses are
amplified via the reverse transcription of viral RNA to viral DNA (vDNA). The nature …

The gold-standard method for quantifying neutralizing antibody responses to many viruses,
including dengue virus (DENV), is the plaque reduction neutralization test (PRNT, also …

The family Arenaviridae is divided into three genera: Mammarenavirus, Reptarenavirus, and
Hartmanivirus. The Mammarenaviruses contain viruses responsible for causing human …

Hemorrhagic fevers (HF) resulting from pathogenic arenaviral infections have traditionally
been neglected as tropical diseases primarily affecting African and South American regions …

Defective interfering particles (DIPs), derived naturally from viral particles, are not able to
replicate on their own. Several studies indicate that DIPs exert antiviral effects via multiple …

There is an urgent need for anti-viral agents that treat SARS-CoV-2 infection. The shortest
path to clinical use is repurposing of drugs that have an established safety profile in humans …

Viral defective interfering particles (DIPs) were intensely studied several decades ago but
research waned leaving open many critical questions. New technologies and other …