The suicide death toll is alarmingly high, outnumbering deaths from war and homicide
worldwide (1). Many factors contribute to suicide death, making it difficult to prevent because …

Objective: Suicide, a major cause of death worldwide, has distinct biological underpinnings.
The authors review and synthesize the research literature on biomarkers of suicide, with the …

Despite a hundred years' research, the neuropathology of schizophrenia remains obscure.
However, neither can the null hypothesis be sustained—that it is afunctional'psychosis, a …

Background Suicide is a major public health concern. Although authors of many studies
have examined the neurobiological aspects of suicide, the molecular mechanisms …

Depression and suicidal behavior have recently been shown to be associated with
disturbances in structural and synaptic plasticity. Brain-derived neurotrophic factor (BDNF) …

Background: The serotonin-1A (5HT1A) receptor system has been implicated in the
pathophysiology of major depression by postmortem studies of suicide victims and …

The aim of this paper is to illustrate a method for identifying macroscopic anatomical
differences among the brains of different populations of subjects. The method involves …

Background Most studies investigating the neurobiology of depression and suicide have
focused on the serotonergic system. While it seems clear that serotonergic alterations play a …

Reduced hippocampal volume is a consistent finding in neuroimaging studies of individuals
with schizophrenia. While these studies have the advantage of large-sample sizes, they are …

Certain animal models can greatly enhance our understanding of the neurobiology of
schizophrenia and can be used to predict the antipsychotic activity of compounds. Prepulse …