Metabolic reprogramming, including enhanced biosynthesis of macromolecules, altered
energy metabolism, and maintenance of redox homeostasis, is considered a hallmark of …

Obesity symbolizes a major public health problem. Overweight and obesity are associated to
the occurrence of the metabolic syndrome and to adipose tissue dysfunction. The adipose …

Hypoxia-inducible factor 1 alpha (HIF-1α) orchestrates cellular adaptation to low oxygen and
nutrient-deprived environment and drives progression to malignancy in human solid …

Adult neurogenesis is a multistage process by which neurons are generated and integrated
into existing neuronal circuits. In the adult brain, neurogenesis is mainly localized in two …

All classic, non-surgical anticancer approaches like chemotherapy, radiotherapy or
photodynamic therapy kill cancer cells by inducing severe oxidative stress. Even tough …

During oncogenesis, cells become unrestrictedly proliferative thereby altering the tissue
homeostasis and resulting in subsequent hyperplasia. This process is paralleled by …

Mutations in the TP53 gene and microenvironmentally driven activation of hypoxia-inducible
factor-1 (HIF-1) typically occur in later stages of tumorigenesis. An ongoing challenge is the …

Maintenance of an appropriate oxygen concentration is essential for the function of the liver.
However, in many pathological conditions, and particularly in the tumor microenvironment …

HIFs have long been associated with resistance to therapy, metastasis, and poor survival
rates in cancer patients. In parallel, although the tumor-suppressor p53 acts as the first …

Abstract Hypoxia-inducible factor 1 (HIF-1) is the founding member of a family of
transcription factors that function as master regulators of oxygen homeostasis. HIF-1 is …