Over the past decade, it has become clear that lipid homeostasis is central to cellular
metabolism. Lipids are particularly abundant in the central nervous system (CNS) where …

Neuroinflammatory and neurodegenerative diseases are a major public health problem
worldwide, especially with the increase of life-expectancy observed during the last decades …

Barth syndrome (BTHS) is a life-threatening genetic disorder with unknown pathogenicity
caused by mutations in TAFAZZIN (TAZ) that affect remodeling of mitochondrial cardiolipin …

Cardiolipin (CL) is a key phospholipid of the mitochondria. A loss of CL content and
remodeling of CL's acyl chains is observed in several pathologies. Strong shifts in CL …

Barth syndrome is a rare X-linked genetic disease classically characterized by
cardiomyopathy, skeletal myopathy, growth retardation, neutropenia, and 3 …

Biomolecular condensates are membraneless organelles (MLOs) that form dynamic,
chemically distinct subcellular compartments organizing macromolecules such as proteins …

Cardiolipin (CL) is a unique, tetra-acylated diphosphatidylglycerol lipid that mainly localizes
in the inner mitochondria membrane (IMM) in mammalian cells and plays a central role in …

Mitochondria are essential for neuronal function because they serve not only to sustain
energy and redox homeostasis but also are harbingers of death. A dysregulated …

Background Dietary fat intake affects brain composition and function. Different types of
dietary fatty acids alter species and abundance of brain lipids in mice. The aim of this study …

Barth syndrome (BTHS) is an X-linked genetic disorder caused by mutations in the
TAFAZZIN/Taz gene which encodes a transacylase required for cardiolipin remodeling …