Mesenchymal stem cells for neurological disorders

A Andrzejewska, S Dabrowska, B Lukomska… - Advanced …, 2021 - Wiley Online Library
Neurological disorders are becoming a growing burden as society ages, and there is a
compelling need to address this spiraling problem. Stem cell‐based regenerative medicine …

Mesenchymal stromal cell therapies: immunomodulatory properties and clinical progress

X Wu, J Jiang, Z Gu, J Zhang, Y Chen, X Liu - Stem cell research & …, 2020 - Springer
Mesenchymal stromal cells (MSCs) are a subset of heterogeneous non-hematopoietic
fibroblast-like cells that can differentiate into cells of multiple lineages, such as …

Immunomodulatory mechanisms of mesenchymal stem cells and their potential clinical applications

Y Huang, Q Wu, PKH Tam - International Journal of Molecular Sciences, 2022 - mdpi.com
Mesenchymal stem cells (MSCs) are multipotent stem cells with the capacity of self-renewal,
homing, and low immunogenicity. These distinct biological characteristics have already …

Paracrine mechanisms of mesenchymal stem cells in tissue repair

M Gnecchi, P Danieli, G Malpasso… - Mesenchymal Stem Cells …, 2016 - Springer
Tissue regeneration from transplanted mesenchymal stromal cells (MSC) either through
transdifferentiation or cell fusion was originally proposed as the principal mechanism …

Immunosuppressive properties of mesenchymal stem cells: advances and applications

MP De Miguel, S Fuentes-Julian… - Current molecular …, 2012 - ingentaconnect.com
Mesenchymal stem cells (MSCs) have been isolated from a variety of tissues, such as bone
marrow, skeletal muscle, dental pulp, bone, umbilical cord and adipose tissue. MSCs are …

Mesenchymal stem cells in health and disease

A Uccelli, L Moretta, V Pistoia - Nature reviews immunology, 2008 - nature.com
Mesenchymal stem cells (MSCs) are a heterogeneous subset of stromal stem cells that can
be isolated from many adult tissues. They can differentiate into cells of the mesodermal …

MSCs: delivery routes and engraftment, cell‐targeting strategies, and immune modulation

TJ Kean, P Lin, AI Caplan, JE Dennis - Stem cells international, 2013 - Wiley Online Library
Mesenchymal stem cells (MSCs) are currently being widely investigated both in the lab and
in clinical trials for multiple disease states. The differentiation, trophic, and …

[HTML][HTML] Mesenchymal stem cell-derived extracellular vesicles ameliorate inflammation-induced preterm brain injury

K Drommelschmidt, M Serdar, I Bendix, J Herz… - Brain, behavior, and …, 2017 - Elsevier
Objective Preterm brain injury is a major cause of disability in later life, and may result in
motor, cognitive and behavioural impairment for which no treatment is currently available …

Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept study

P Connick, M Kolappan, C Crawley… - The Lancet …, 2012 - thelancet.com
Background More than half of patients with multiple sclerosis have progressive disease
characterised by accumulating disability. The absence of treatments for progressive multiple …

Stem cell paracrine actions and tissue regeneration

PR Baraniak, TC McDevitt - Regenerative medicine, 2010 - Taylor & Francis
Stem cells have emerged as a key element of regenerative medicine therapies due to their
inherent ability to differentiate into a variety of cell phenotypes, thereby providing numerous …