Aging, hypertension, diabetes, hypoxia/obstructive sleep apnea (OSA), obesity, vitamin
B12/folate deficiency, depression, and traumatic brain injury synergistically promote diverse …

Sporadic cerebral amyloid angiopathy (CAA) is a very common small vessel disease of the
brain, showing preferential and progressive amyloid-βdeposition in the wall of small …

Purpose [18 F] FDG is a commonly used neuronal injury biomarker for early and differential
diagnosis of dementia. Typically, the blood supply to the brain is closely coupled to glucose …

The PET tracer 11C-deuterium-L-deprenyl (11C-DED) has been used to visualize activated
astrocytes in vivo in patients with Alzheimer disease (AD). In this multitracer PET study, early …

For amyloid positron emission tomography tracers, the simplified reference tissue model
derived ratio of influx rate in target relative to reference region (R1) has been shown to serve …

Because a correlation between tau pathology and the clinical symptoms of Alzheimer
disease (AD) has been hypothesized, there is increasing interest in developing PET tracers …

In Alzheimer's Disease (AD) dual-tracer positron emission tomography (PET) studies with 2-
[18F]-fluoro-2-deoxy-D-glucose (FDG) and 11C-labelled Pittsburgh Compound B (PIB) are …

Surrogates of neuronal activity, typically measured by regional cerebral blood flow (rCBF) or
glucose metabolism, can be estimated from dynamic amyloid PET imaging. Using data for …

Alzheimer disease (AD) neuropathologic changes are β-amyloid (Aβ) deposition, pathologic
tau, and neurodegeneration. Dual-phase amyloid PET might be able to evaluate Aβ …

PET based tools can improve the early diagnosis of Alzheimer's disease (AD) and
differential diagnosis of dementia. The importance of identifying individuals at risk of …