Diabetic nephropathy: perspective on novel molecular mechanisms
L Gnudi, RJM Coward, DA Long - Trends in Endocrinology & Metabolism, 2016 - cell.com
Diabetes mellitus (DM) is the major cause of end-stage renal disease (ESRD) globally, and
novel treatments are urgently needed. Current therapeutic approaches for diabetic …
novel treatments are urgently needed. Current therapeutic approaches for diabetic …
Role of NAD+ and mitochondrial sirtuins in cardiac and renal diseases
KA Hershberger, AS Martin, MD Hirschey - Nature Reviews Nephrology, 2017 - nature.com
The coenzyme nicotinamide adenine dinucleotide (NAD+) has key roles in the regulation of
redox status and energy metabolism. NAD+ depletion is emerging as a major contributor to …
redox status and energy metabolism. NAD+ depletion is emerging as a major contributor to …
Andrographolide ameliorates diabetic nephropathy by attenuating hyperglycemia-mediated renal oxidative stress and inflammation via Akt/NF-κB pathway
X Ji, C Li, Y Ou, N Li, K Yuan, G Yang, X Chen… - Molecular and cellular …, 2016 - Elsevier
Diabetic nephropathy (DN) is characterized by proliferation of mesangial cells, mesangial
hypertrophy and extracellular matrix (ECM) accumulation. Our recent study found that …
hypertrophy and extracellular matrix (ECM) accumulation. Our recent study found that …
[HTML][HTML] Roles and mechanisms of the CD38/cyclic adenosine diphosphate ribose/Ca2+ signaling pathway
W Wei, R Graeff, J Yue - World journal of biological chemistry, 2014 - ncbi.nlm.nih.gov
Mobilization of intracellular Ca 2+ stores is involved in many diverse cell functions,
including: cell proliferation; differentiation; fertilization; muscle contraction; secretion of …
including: cell proliferation; differentiation; fertilization; muscle contraction; secretion of …
Involvement of endoplasmic reticulum stress, autophagy and apoptosis in advanced glycation end products-induced glomerular mesangial cell injury
Advanced glycation end-products (AGEs)-induced mesangial cell death is one of major
causes of glomerulus dysfunction in diabetic nephropathy. Both endoplasmic reticulum (ER) …
causes of glomerulus dysfunction in diabetic nephropathy. Both endoplasmic reticulum (ER) …
[HTML][HTML] Astragaloside IV prevents damage to human mesangial cells through the inhibition of the NADPH oxidase/ROS/Akt/NF‑κB pathway under high glucose …
L Sun, W Li, W Li, L Xiong, G Li… - … Journal of Molecular …, 2014 - spandidos-publications.com
Glomerular hypertrophy and hyperfiltration are the two major pathological characteristics of
the early stages of diabetic nephropathy (DN), which are respectively related to mesangial …
the early stages of diabetic nephropathy (DN), which are respectively related to mesangial …
Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Cyclic ADP-Ribose (cADPR) Mediate Ca2+ Signaling in Cardiac Hypertrophy Induced by β-Adrenergic …
R Gul, DR Park, AI Shawl, SY Im, TS Nam, SH Lee… - PloS one, 2016 - journals.plos.org
Ca2+ signaling plays a fundamental role in cardiac hypertrophic remodeling, but the
underlying mechanisms remain poorly understood. We investigated the role of Ca2+ …
underlying mechanisms remain poorly understood. We investigated the role of Ca2+ …
CD38-mediated Ca2+ signaling contributes to angiotensin II-induced activation of hepatic stellate cells: attenuation of hepatic fibrosis by CD38 ablation
SY Kim, BH Cho, UH Kim - Journal of biological chemistry, 2010 - ASBMB
CD38 is a type II glycoprotein that is responsible for the synthesis and hydrolysis of cyclic
ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP), Ca 2+ …
ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP), Ca 2+ …
Omega-3 fatty acids induce Ca2+ mobilization responses in human colon epithelial cell lines endogenously expressing FFA4
J Kim, K Lee, S Park, S Kang, J Huang, J Lee… - Acta Pharmacologica …, 2015 - nature.com
Aim: Free fatty acid receptor 4 (FFA4; formerly known as GPR120) is the G protein-coupled
receptor (GPCR) for omega-3 polyunsaturated fatty acids. FFA4 has been found to express …
receptor (GPCR) for omega-3 polyunsaturated fatty acids. FFA4 has been found to express …
Gain of function of cardiac ryanodine receptor in a rat model of type 1 diabetes
C Tian, C Hong Shao, CJ Moore, S Kutty… - Cardiovascular …, 2011 - academic.oup.com
Aims Ventricular myocytes isolated from hearts of streptozotocin (STZ)-diabetic rats exhibit
increased spontaneous Ca2+ release. Studies attribute this defect to an enhancement in …
increased spontaneous Ca2+ release. Studies attribute this defect to an enhancement in …