Clinical development of metal complexes as photosensitizers for photodynamic therapy of cancer

J Karges - Angewandte chemie international edition, 2022 - Wiley Online Library
Cancer has emerged over the last decades as one of the deadliest diseases in the world.
Among the most commonly used techniques (ie surgery, immunotherapy, radiotherapy or …

Luminescent and photofunctional transition metal complexes: From molecular design to diagnostic and therapeutic applications

LCC Lee, KKW Lo - Journal of the American Chemical Society, 2022 - ACS Publications
There has been emerging interest in the exploitation of the photophysical and
photochemical properties of transition metal complexes for diagnostic and therapeutic …

Coupling probiotics with 2D CoCuMo‐LDH nanosheets as a tumor‐microenvironment‐responsive platform for precise NIR‐II photodynamic therapy

Y Yang, T Hu, Y Bian, F Meng, S Yu, H Li… - Advanced …, 2023 - Wiley Online Library
Photodynamic therapy (PDT) has become a promising cancer treatment approach with
superior advantages. However, it remains a grand challenge to develop tumor …

Photodecaging of a mitochondria-localized iridium (III) endoperoxide complex for two-photon photoactivated therapy under hypoxia

S Kuang, F Wei, J Karges, L Ke, K Xiong… - Journal of the …, 2022 - ACS Publications
Despite the clinical success of photodynamic therapy (PDT), the application of this medical
technique is intrinsically limited by the low oxygen concentrations found in cancer tumors …

Cancer therapeutics based on diverse energy sources

S Son, J Kim, J Kim, B Kim, J Lee, Y Kim, M Li… - Chemical Society …, 2022 - pubs.rsc.org
Light-based phototherapy has been developed for cancer treatment owing to its non-
invasiveness and spatiotemporal control. Despite the unique merits of phototherapy, one …

In response to precision medicine: Current subcellular targeting strategies for cancer therapy

Z Li, J Zou, X Chen - Advanced Materials, 2023 - Wiley Online Library
Emerging as a potent anticancer treatment, subcellular targeted cancer therapy has drawn
increasing attention, bringing great opportunities for clinical application. Here, two targeting …

A Biodegradable Iridium (III) Coordination Polymer for Enhanced Two‐Photon Photodynamic Therapy Using an Apoptosis–Ferroptosis Hybrid Pathway

L Ke, F Wei, L Xie, J Karges, Y Chen… - Angewandte Chemie …, 2022 - Wiley Online Library
The clinical application of photodynamic therapy is hindered by the high glutathione
concentration, poor cancer‐targeting properties, poor drug loading into delivery systems …

Ferroptosis‐enhanced cancer immunity by a ferrocene‐appended iridium (III) Diphosphine complex

WJ Wang, YY Ling, YM Zhong, ZY Li… - Angewandte Chemie …, 2022 - Wiley Online Library
Ferroptosis is a programmed cell death pathway discovered in recent years, and ferroptosis‐
inducing agents have great potential as new antitumor candidates. Here, we report a IrIII …

[HTML][HTML] Enzyme-triggered deep tumor penetration of a dual-drug nanomedicine enables an enhanced cancer combination therapy

L Gu, Z Duan, X Li, X Li, Y Li, X Li, G Xu, P Gao… - Bioactive Materials, 2023 - Elsevier
Cancer cells could be eradicated by promoting generation of excessive intracellular reactive
oxygen species (ROS) via emerging nanomedicines. However, tumor heterogeneity and …

[HTML][HTML] A highly potent ruthenium (II)-sonosensitizer and sonocatalyst for in vivo sonotherapy

C Liang, J Xie, S Luo, C Huang, Q Zhang… - Nature …, 2021 - nature.com
As a basic structure of most polypyridinal metal complexes,[Ru (bpy) 3] 2+, has the
advantages of simple structure, facile synthesis and high yield, which has great potential for …