[HTML][HTML] Cancer is a preventable disease that requires major lifestyle changes
P Anand, AB Kunnumakara, C Sundaram… - Pharmaceutical …, 2008 - Springer
This year, more than 1 million Americans and more than 10 million people worldwide are
expected to be diagnosed with cancer, a disease commonly believed to be preventable …
expected to be diagnosed with cancer, a disease commonly believed to be preventable …
Insulin and insulin-like growth factor signalling in neoplasia
M Pollak - Nature Reviews Cancer, 2008 - nature.com
Insulin and insulin-like growth factors (IGFs) are well known as key regulators of energy
metabolism and growth. There is now considerable evidence that these hormones and the …
metabolism and growth. There is now considerable evidence that these hormones and the …
[HTML][HTML] Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population
Mice and humans with growth hormone receptor/IGF-1 deficiencies display major reductions
in age-related diseases. Because protein restriction reduces GHR-IGF-1 activity, we …
in age-related diseases. Because protein restriction reduces GHR-IGF-1 activity, we …
The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies
M Maalouf, JM Rho, MP Mattson - Brain research reviews, 2009 - Elsevier
Both calorie restriction and the ketogenic diet possess broad therapeutic potential in various
clinical settings and in various animal models of neurological disease. Following calorie …
clinical settings and in various animal models of neurological disease. Following calorie …
Annual report to the nation on the status of cancer, 1975‐2008, featuring cancers associated with excess weight and lack of sufficient physical activity
BACKGROUND: Annual updates on cancer occurrence and trends in the United States are
provided through collaboration between the American Cancer Society (ACS), the Centers for …
provided through collaboration between the American Cancer Society (ACS), the Centers for …
Targeting metabolism for cancer treatment and prevention: metformin, an old drug with multi-faceted effects
MA Pierotti, F Berrino, M Gariboldi, C Melani… - Oncogene, 2013 - nature.com
Understanding the complexity of cancer and of the underlying regulatory networks provides
a new paradigm that tackles cancer development and treatment through a system biology …
a new paradigm that tackles cancer development and treatment through a system biology …
Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice
MS Yates, QT Tran, PM Dolan, WO Osburn… - …, 2009 - academic.oup.com
Loss of NF-E2-related factor 2 (Nrf2) signaling increases susceptibility to acute toxicity,
inflammation and carcinogenesis in mice due to the inability to mount adaptive responses. In …
inflammation and carcinogenesis in mice due to the inability to mount adaptive responses. In …
Physical activity and global genomic DNA methylation in a cancer-free population
FF Zhang, R Cardarelli, J Carroll, S Zhang, KG Fulda… - Epigenetics, 2011 - Taylor & Francis
Changes in DNA methylation may represent an intermediate step between the environment
and human diseases. Little is known on whether behavioral risk factors may modify gene …
and human diseases. Little is known on whether behavioral risk factors may modify gene …
Calories and carcinogenesis: lessons learned from 30 years of calorie restriction research
SD Hursting, SM Smith, LM Lashinger… - …, 2010 - academic.oup.com
Calorie restriction (CR) is arguably the most potent, broadly acting dietary regimen for
suppressing the carcinogenesis process, and many of the key studies in this field have been …
suppressing the carcinogenesis process, and many of the key studies in this field have been …
Effects of calorie restriction and diet-induced obesity on murine colon carcinogenesis, growth and inflammatory factors, and microRNA expression
SE Olivo-Marston, SD Hursting, SN Perkins, A Schetter… - PloS one, 2014 - journals.plos.org
Obesity is an established colon cancer risk factor, while preventing or reversing obesity via a
calorie restriction (CR) diet regimen decreases colon cancer risk. Unfortunately, the …
calorie restriction (CR) diet regimen decreases colon cancer risk. Unfortunately, the …