Calcitonin gene-related peptide (CGRP) is a neuropeptide with diverse physiological
functions. Its two isoforms (α and β) are widely expressed throughout the body in sensory …

The underlying causes of migraine headache remained enigmatic for most of the 20th
century. In 1979, The Lancet published a novel hypothesis proposing an integral role for the …

For the past two decades, the function of intrabony nerves on bone has been a subject of
intense research, while the function of bone on intrabony nerves is still hidden in the corner …

Migraine is the most prevalent neurological disorder worldwide and it has immense
socioeconomic impact. Currently, preventative treatment options for migraine include drugs …

Migraine and neuropathic pain (NP) are both painful, disabling, chronic conditions which
exhibit some symptom similarities and are thus considered to share a common etiology. The …

Migraine is a complex disorder characterized by recurrent episodes of headache, and is one
of the most prevalent and disabling neurological disorders. A key feature of migraine is that …

The neuronal engagement of the peripheral nerve system plays a crucial role in regulating
fracture healing, but how to modulate the neuronal activity to enhance fracture healing …

Musculoskeletal pain is a condition that characterises several diseases and represents a
constantly growing issue with enormous socio-economic burdens, highlighting the …

Intervertebral disc degeneration (IVDD) has been the major contributor to chronic lower back
pain (LBP). Abnormal apoptosis, senescence, and pyroptosis of IVD cells, extracellular …

Neuropeptides and neurotrophins are key regulators of peripheral nociceptive nerves and
contribute to the induction, sensitization, and maintenance of pain. It is now known that these …