The earliest recorded application of therapeutic hypothermia in medicine spans about 5000
years; however, its use has become widespread since 2002, following the demonstration of …

Critically ill pediatric patients often require complex medical procedures as well as invasive
testing and monitoring which tend to be painful and anxiety-provoking, necessitating the …

Treatment of brain injury following circulatory arrest is a challenging health issue with no
viable therapeutic options. Based on studies in a clinically relevant large animal (canine) …

Neonatal seizures constitute the most frequent presenting neurologic sign encountered in
the neonatal intensive care unit. Despite limited efficacy and safety data, phenobarbital …

Seizures are the most common neurological emergencies in the neonatal period and are
associated with poor neurodevelopmental outcomes. Seizures affect up to five per 1000 …

Therapeutic hypothermia is the only treatment currently recommended for moderate or
severe encephalopathy of hypoxic‒ischaemic origin in term neonates. Though the effects of …

Objective Neurological outcome prediction is crucial early after cardiac arrest. Serum
biomarkers released from brain cells after hypoxic-ischaemic injury may aid in outcome …

Introduction Perinatal asphyxia (PA) still causes significant morbidity and mortality.
Therapeutic hypothermia (TH) is the only effective therapy for neonates with moderate to …

Introduction: All critically ill patients require medication to treat organ dysfunction. However,
the pharmacokinetics of drugs used to treat these patients is complex due to frequent …

Therapeutic hypothermia (TH) may induce pharmacokinetic changes that may affect the
level of sedation. We have compared the disposition of morphine, midazolam, fentanyl, and …